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  Previous issue (2019. Vol. 8, no. 2)

Journal of Modern Foreign Psychology

Publisher: Moscow State University of Psychology and Education

ISSN (online): 2304-4977

DOI: http://dx.doi.org/10.17759/jmfp

License: CC BY-NC 4.0

Started in 2012

Published quarterly

Free of fees
Open Access Journal

 

Modeling of human brain diseases in experiments on rodents (brief overview) 1185

Perepelkina O.V., PhD in Biology, Moscow, Russia, o_perepel73@mail.ru
Poletaeva I.I., PhD in Biology, Moscow, Russia, ingapoletaeva@mail.ru
Tarasova A.Yu., Moscow, Russia, odrima@yandex.ru
Abstract
The review summarizes the successes and difficulties in creating and using biological models of the human brain diseases, which belongs to the important issues of applied Neurobiology. The review mentions and attempts to theoretically comprehend the relative role of genotype, environmental influences and their dynamic interactions (LEARN concept). The article reviews the examples of developed genetic models of human diseases (Alzheimer's, Down syndrome, Autism, etc.). When creating models of anxiety disorders the focus is made on the difficult problem of "norm" and "pathology", as well as the importance of integrating and understanding species specific behavior of animals used as biological models of this kind.

Keywords: neurogenetics, behavioral genetics, genetic models, human brain diseases, models of anxiety disorders, genotype-environment interaction

Column: Neurosciences

DOI: http://dx.doi.org/10.17759/jmfp.2016050402

For Reference

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