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Psychological-Educational Studies

Former Title: Psychological Science and Education

Publisher: Moscow State University of Psychology and Education

ISSN (online): 2587-6139


Started in 2009

Published quarterly

Free of fees
Open Access Journal


Modern Approaches to Diagnosis and Treatment of Cognitive Disorders in Children and Adults

Gorbachevskaya N.L., Doctor in Biology, Head of the Research and Education Center , Research and Education Center "Neurobiological Diagnosis Of Hereditary Mental Disorders Of Children And Adolescents", Moscow State University of Psychology and Education, Moscow, Russia,
The article regards etiology and pathogenesis of some inherited mental diseases which are entailed frank cognitive disorders. It describes psychoneurological disorders during diseases such as neurofibromatosis, tuberous sclerosis, X-linked mentally retardation syndrome, Rett's syndrome. Their separation from the group of undifferential forms becomes available with improvement of genetic methods of analysis. Defining genes in which mutations entailed disorders in mental development gives an opportunity to create models of these disorders on animals and study their pathogenesis mechanisms. The article discusses approaches to therapy of cognitive disorders based on understanding of signal pathway functioning. It also presents first results of pathogeneticaly valid therapy.

Keywords: inherited mental diseases, cognitive disorders, pathogenesis, therapy.

Column: Clinical Psychology

For Reference

  1. Belichenko N. P., Belichenko P.V., Li Vong Hua, Moble W. C., Frank U. Comparative Study Of Brain Morphology. In Mecp2 Mutant Mouse Models of Rett Syndrome // The Journal оf Comparative Neurology. 2008. 508.
  2. Ehninger D., de Vries P. J., Silva A. J. From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis // Journal of Intellectual Disability Research. October 2009. Vol. 53.
  3. Sahin A. M. et al. A mouse model of tuberous sclerosis: neuronal loss of TSC icauses dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival // Journal of  Neuroscience. 2007.
  4. Voinova-Ulas V. Yu., Iourov I. Yu., Gorbachevskaya N. L., Boudilov A.V., Demidova I. A., Giunti L., Sorokin A. B., Prassolov V. S., Villard L. Towards genotype-phenotype correlationsin Rett syndrome: the study of MECP2 mutations and X chromosome inactivation // Gene. Brain. Behavior. Edited by S. B. Malych, A. M. Torgersen. Oslo-Moscow, 2007.
  5. De Vries P. J., Oliver Ch. Intellectual disabilities and genetic disorders can lead the way in translational research // Journal of Intellectual Disability Research. October 2009. Vol. 53.
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