Update on behavioral interventions for autism and developmental disabilities 1465
, international expert on autism, Semel Institute, University of California, Los Angeles (UCLA), USA, email@example.com
An uptick in the number of rigorous tests of different interventions conducted in real-world settings with outcomes focused on core deficits bodes well for wide dissemination and implementation by nonspecialists in the community. Pilot and un¬controlled data on prevention and mechanism await further rigorous testing before conclusions can be drawn.
Kaplan ., McCracken J.T. Psychopharmacology of
autism spectrum disorders. Pediatr Clin North Am 2012; 59:175—187.
Fletcher-Watson S., McConnell F., Manola E., et al.
Interventions based on the Theory of Mind cognitive model for autism spectrum
disorder (ASD). Cochrane Database Syst. Rev. 2014; 3:CD008785.
Oono I.P, Honey E. Autism spectrum disorders (ASD).
Cochrane Database Syst. Rev. 2013; 4:CD009774.
Reichow B., Steiner A.M., Volkmar F. Social skills
groups for people aged 6 to 21 with autism spectrum disorders (ASD). Cochrane
Database Syst. Rev. 2012; 7:CD008511.
U.S. Department of Education, National Center for
Education Statistics. (2013). The Digest of Education Statistics, 2012 (NCES
2014-015). Table 50.
Tager-Flusberg H., Kasari C. Minimally verbal
school-age children with autism: the neglected end of the spectrum. Autism Res
Fein D., Barton M., Eigsti I.M., et al. Optimal
outcome in individuals with a history of autism. J Child Psychol. Psychiatry,
Rogers S.J., Vismara L., Wagner A.L., McCormick C., et
al. Autism treatment in the first year of life: a pilot study of infant
start, a parent-implemented intervention for symptomatic infants. J Autism Dev.
Disorder, 2014; 44: 2981—2995. Case controlled study of seven 10—12-month-old
infants at risk for ASD with suggestion that early parent-mediated intervention
can prevent the development of ASD at age 3 years.
Kasari C., Smith T. Interventions in schools for
children with autism spectrum disorder: methods and recommendations. Autism
Lovaas O.I. Behavioral treatment and normal
educational and intellectual functioning in young autistic children. J Consult
Clin Psychol 1987; 55: 3—9.
Smith T., Green A., Wynn J. Randomized trial of
intensive early intervention for children with pervasive developmental
disorder. Am J Ment Retard 2000; 105:269—285.
Buescher A.V., Cidav Z., Knapp M., Mandell D.S.
Costs of autism spectrum disorders in the United Kingdom and the United States.
JAMA Pediatr 2014; 168:721—728.
Lavelle T.A., Weinstein M.C., Newhouse J.P., Munir K.,
et al. Economic burden of childhood autism spectrum disorders. Pediatrics
Fey M.E., Yoder P.J., Warren S.F., Bredin-Oja S. Is
more better? Milieu communication teaching in toddlers with intellectual
disabilities. J Speech Lang Hear Res 2013; 56:679—693.
Yoder P.J., Woynaroski T., Fey M., Warren S.
Effects of dose frequency of early communication intervention in young children
with and without Down syndrome. Am J Intell Dev. Disab., 2014; 119:17—32.
Reanalysis of primary study demonstrates that dose appears more important for
improving vocabulary growth in children with Down syndrome than children with
general intellectual disabilities.
Hauser C.T., Kover S.T., Abbeduto L. Maternal well
being and child behavior in families with fragile X syndrome. Res. Dev.
Disabil., 2014; 35:2477—2486.
Hustyi K.M., Hall S.S., Jo B., et al. Longitudinal
trajectories of aberrant behavior in fragile x syndrome. Res. Dev. Disabil,
Klusek J., Martin G.E., Losh M.A. Comparison of
pragmatic language in boys with autism and fragile X syndrome. J Speech Lang.
Hear. Res., 2014; 57: 1692—1707.
Anderson D.K., Liang J.W., Lord C. Predicting young
adult outcome among more and less cognitively able individuals with autism
spectrum disorders. J Child. Pscychol. Psychiatry, 2014; 55:485—494.
Sigman M., Ruskin E. Continuity and change in the
social competence of children with autism, Down syndrome, and developmental
delays. Monogr Soc Res Child Dev 1999; 64:1—114.
Weisz J.R., Chorpita B.F., Palinkas L.A., Schoenwald
S.K., et al. Testing standard and modular designs for psychotherapy
treating depression, anxiety, and conduct problems in youth: a randomized
effectiveness trial. Arch. Gen. Psychiatry, 2012; 69:274—282. doi:
Chorpita B.F., Weisz J.R., Daleiden E.L., Schoenwald
S.K., et al. Long-term outcomes for the Child STEPs randomized
effectiveness trial: a comparison of modular and standard treatment designs
with usual care. J Consult Clin Psychol 201; 81:999—1009. doi:
Kasari C., Lawton K., ShihW., Barker T.V., et al.
Caregiver-mediated intervention for low-resourced preschoolers with autism: an
RCT 2014. Pediatrics ; 134: e72—e79. Randomized trial comparing two parent
focused interventions found parent coaching needed to improve core deficits of
social communication in low-resourced preschoolers with ASD.
Chambless D.L., Hollon S.D. Defining empirically
supported therapies. J Consult. Clin. Psychol., 1988; 66:7—18.
Kasari C., Freeman S., Paparella T. Joint attention
and symbolic play in young children with autism: a randomized controlled
intervention study. J Child Psychol Psychiatry 2006; 47:611—620.
Kasari C., Gulsrud A.C., Wong C., et al. A
randomized controlled caregiver mediated joint engagement intervention for
toddlers with autism. J Autism Dev. Disord., 2010; 40:1045—1056.
Kasari C., Kaiser A., Goods K., et al.
Communication interventions for minimally verbal children with autism: a
sequential multiple assignment randomized trial. J Am. Acad. Child. Adolesc.
Psychiatry, 2014; 53:635—646.
Wetherby A., Guthrie W., Woods J., et al.
Parent-implemented social intervention for toddlers with autism: an RCT.
Pediatrics 2014; 134:1—10. Randomized trial of two parent involved
interventions for toddlers with ASD found significant benefit of parent
coaching in the home on child social communication outcomes and receptive
Siller M., Hutman T., Sigman M. A parent mediated
intervention to increase responsive parental behaviors and child communication
in children with ASD: a randomized clinical trial. J Autism Dev. Disord., 2013;
43:540—555. doi: 10.1007/s10803-012-1584-y.
Kasari C., Siller M., Huynh L.N., et al. Randomized
controlled trial of parental responsiveness intervention for toddlers at high
risk for autism. Infant Behav Dev 2014; 37:711—721. Randomized trial of parent
education model for at risk for ASD toddlers found significant short-term gain
in parent responsiveness but no measurable effect on child outcome.
Solomon R.1., Van Egeren L.A., Mahoney G., et al.
PLAY Project Home Consultation intervention program for young children with
autism spectrum disorders: a randomized controlled trial. J Dev Behav Pediatr
2014; 35:475- 485. Randomized trial of relationship based parent—child
intervention used a consultation model over one year with significant benefit
in parent responsiveness and child initiations in interaction with
Harden A.Y., Gengoux G.W., Berquist K.L., Libove R.A.,
et al. A randomized controlled trial of Pivotal Response Treatment Group
for parents of children with autism. J Child Psychol Psychiatry 2014; DOI:
10.1111/ jcpp.12354. Randomized group delivered model of Pivotal Response
Treatment superior in child prompted language outcomes compared to group model
focused on general ASD information.
Paul R., Campbell D., Gilbert K., Tsiouri I.
Comparing spoken language treatments for preschoolers with autism spectrum
disorder. J Autism Dev. Disord., 2014. doi: 10.1007/s10803-012-1583-z. Small
randomized trial comparing two communication interventions with minimally
verbal preschoolers, no significant treatment differences.
Schreibman L., Stahmer A. A randomized trial
comparison of the effects of verbal and pictorial naturalistic communication
strategies on spoken language for young children with autism. J Autism Dev
Disord 2014; 44:1244-1251. doi:10.1007/s10803-013-1972-y. Small randomized
trial comparing pictorial communication treatment to pivotal response treatment
did not yield treatment differences for minimally verbal preschoolers.
Harrop C., Shire S., Gulsrud A., Chang Y.C., et al.
Does gender influence core deficits in ASD? An investigation into
social-communication and play of girls and boys with ASD. J Autism Dev.
Frazier T.W., Georgiades S., Bishop S.L., Hardan
A.Y. Behavioral and cognitive characteristics of females and males with
autism in the Simons Simplex Collection. J Am Acad Child Adolesc Psychiatry
Head A.M., McGillivray J.A., Stokes M.A. Gender
differences in emotionality and sociability in children with autism spectrum
disorders. Mol Autism 2014; 5:19. doi: 10.1186/2040-2392-5-19.
Dean M., Kasari C., Shih W., Frankel F., et al. The
peer relationships of girls with ASD at school: comparison to boys and girls
with and without ASD. J Child Psychol. Psychiatry ; 55:1218—1225.
Ranson N.J., Byrne M.K. Promoting peer acceptance
of females with higherfunctioning autism in a mainstream education setting: a
replication and extension of the effects of an autism antistigma program. J
Autism Dev. Disord. 2014; 44:2778—2796. Randomized trial of peer acceptance
intervention for girls with and without ASD at school yielded greater
acceptance but not necessarily generalization to other contexts.
ShihW., Patterson S., Kasari C. Developing an
adaptive treatment strategy for peer-related social skills for children with
autism spectrum disorders. J Clin. Child. Adolesc. Psychol., 2014; DOI:
Kaale A., Fagerland M.W., Martinsen E.W., Smith L.
Preschool-based social communication treatment for children with autism:
12-month follow-up of a randomized trial. J Assoc. Am. Child Adolesc.
Psychiatry., 2014; 53:188— 198. Follow-up to randomized trial of
teacher-implemented joint attention intervention yielded significant
maintenance of child outcomes.
Kretzmann M., Shih W., Kasari C. Improving peer
engagement on the school playground: a randomized controlled trial. Behav Ther
2015; 46:20—28. Small randomized trial of recess intervention successfully
trained paraprofessionals on the playground to engage children with ASD, and
children with ASD demonstrated generalized engagement with peers.
Ventola P.1., Yang D.Y., Friedman H.E., Oosting D., et
al. Heterogeneity of neural mechanisms of response to pivotal response
treatment. Brain Imaging Behav 2014; DOI 10.1007/s11682-014-9331-y. Prepost
fMRI of biological motion paradigm of 10 children who received 16 weeks of
Pivotal Response Treatment with apparent brain changes; unclear conclusions
given no control group, or rigorous design.