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  Previous issue (2022. Vol. 20, no. 1)

Autism and Developmental Disorders

Publisher: Moscow State University of Psychology and Education

ISSN (printed version): 1994-1617

ISSN (online): 2413-4317


License: CC BY-NC 4.0

Published since 2003

Published quarterly

Free of fees
Open Access Journal


Integrating Treatment for Autism: Psychiatric Comorbidities and Comprehensive Treatment 408


Parenteau C.I.
Clinical Research Coordinator of the Department of Psychiatry, University of California San Francisco, San Francisco, USA

Tsipan R.M.
Research Assistant of the Department of Psychiatry, University of California Berkeley, San Francisco

Hendren R.L.
Professor of Psychiatry, Director of Program for Research on Neurodevelopmental and Translational Outcomes (PRONTO), University of California San Francisco, San Francisco

Autism Spectrum Disorder (ASD) treatment becomes more convoluted when additional mental disorders are present. Comorbidities with ASD discussed in this review include attention deficit hyperactivity disorder (ADHD), anxiety, depression, disruptive mood dysregulation disorder (DMDD), psychotic and bipolar disorder. As these disorders typically affect multiple endophenotypes, from genetics to behavior, treatment must aim to target multiple layers, all the while minimizing side effects. Evidence-based therapies for ASD and comorbidities can range from psychosocial interventions to psychotropic medicines, with a varying degree of effectiveness for pairings of comorbidities and combinations of treatment. This review aims to create a brief overview of ASD comorbidities and discuss treatment options based on prior evidence-based research. Appropriate treatment is dependent on specific symptomatology, but evidence suggests that integrative-targeted treatment is typically more effective than stand-alone treatments.

Keywords: autism, comorbidities, endophenotypes, integrative medicine, psychosocial interventions, psychopharmological treatment, drug treatment

Column: Medical support


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