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Psychic State and Cognitive Function in HIV-infected Patients and Functional State of the Brain Structures (According to Positron Emission Tomography and Magnetic Resonance Spectroscopy) 141
Gromova E.A.
PhD in Medicine, Head of the Department, Radiology Department, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0001-7723-8242
e-mail: gromova@ihb.spb.ru Kataeva G.V.
PhD in Biology, Scientific Director, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0003-0463-9832
e-mail: galina@ihb.spb.ru Khomenko I.G.
PhD in Psychology, Researcher, Neuroimaging Laboratory, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0001-7593-499X
e-mail: khomenko@ihb.spb.ru Kotomin I.A.
Engineer, Radiology Department, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0002-8966-4107
e-mail: kotomin@ihb.spb.ru Bogdan A.A.
Junior Researcher of the Laboratory of Stereotactic Methods, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0002-2836-1516
e-mail: andrey@ihb.spb.ru
The article presents the results of the study of cognitive functions and the psychic state of HIV-infected patients. 38 patients aged 25-45 years were examined. In HIV-infected patients, dysfunctions of the central nervous system observed, which could be detected in the early stages after infection. Indicators of cognitive functions and psychic state correlated with the metabolism of the cerebral cortex, mainly with the metabolism of structures associated with executive functions. Obviously, patients of presented category have a decline in executive functions. Therefore, it is important to include psychocorrective treatment aimed at training of emotional-volitional functions, in the rehabilitation program which should also contribute to the improvement of cognitive functions and better social adaptation. The revealed changes in glucose metabolism and the content of N-acetyl aspartate were nonspecific and could be caused by a combination of the direct effect of the virus on the brain tissue, psychogenic and premorbid factors. Most likely, the existing premorbid features enhanced by the toxic effects of HIV and severe psycho-emotional stress associated with obtaining information about infection.
- Akulova M.V. Sotsial'no-psikhologicheskie problemy integratsii v
sotsium semei, zatronutykh epidemiei VICh-infektsii [The socio-psychological
challenges of the integration of families affected by HIV infection into
socialty]. Konsul'tativnaya psikhologiya i psikhoterapiya [Counseling
Psychology and Psychotherapy], 2015, vol. 23, no. 4, pp. 69–82.
doi:10.17759/cpp.2015230405. (In Russ., аbstr. in Engl.)
- Gaisina A.V., Magonov E.P., Gromova E.A., et al. Patologicheskie mekhanizmy
VICh-assotsiirovannykh neirokognitivnykh rasstroistv [Pathological mechanisms
of HIV-associated neurocognitive frustration] Luchevaya diagnostika i
terapiya [Diagnostic Radiology and Radiotherapy], 2016, vol. 7, no 2, pp.
6–21. (in Russ., abstr. in Engl.)
- Gromova E.A., Bogdan A.A., Kataeva G.V., et al. Osobennosti
funktsional'nogo sostoyaniya struktur golovnogo mozga u VICh-infitsirovannykh
patsientov. [Peculiarities of the brain functional state in HIV patients].
Luchevaya diagnostika i terapiya [Diagnostic Radiology and
Radiotherapy], 2016, vol. 7, no. 1, pp. 41–48. (in Russ., abstr. in
Engl.).
- Gromova E.A. Metabolicheskie izmeneniya v golovnom mozge u
VICh-infitsirovannykh patsientov po dannym pozitronno-emissionnoi tomografii s
2-18F-ftordezoksi D-glyukozoi i protonnoi magnitno-rezonansnoi spektroskopii.
Diss. kand. med. nauk [Metabolic changes in the brain of HIV positive patients
according to the PET and MRS data. PhD (medicine) Thesis].
Saint-Petersburg, 2018. 120 p.
- Kataeva G.V., Korotkov A.D., Mel'nichuk K.V. Patterny otnositel'nykh
otsenok regionarnogo mozgovogo krovotoka i skorosti metabolizma glyukozy v
zdorovom mozge cheloveka [Patterns of relative values of regional cerebral
blood flow and glucose metabolism rate in the healthy human brain].
Meditsinskaya vizualizatsiya [Medical Neuroimaging], 2007, no. 2, pp.
84–92. (in Russ.)
- Makhamatova, A.F. The Problem of Relationships Between Doctor and
HIV-Infected Patient [Elektronnyi resurs]. Klinicheskaia i spetsial'naia
psikhologiia [Clinical Psychology and Special Education], 2016, vol. 5, no.
2, pp. 23–32. doi: 10.17759/psycljn. 2016050202 (In Russ., abstr. in
Engl.)
- Medvedev S.V., Skvortsova T.Yu., Krasikova R.N. PET v Rossii:
pozitronno-emissionnaya tomografiya v klinike i fiziologii [PET in Russia:
positron emission tomography in clinics and physiology]. Saint-Petersburg: AST,
2008. 318 p. (in Russ.)
- Neznanov N.G., Khalezova N.B. Osobennosti sovladayushchego povedeniya u
VICh-infitsirovannykh bol'nykh. [Peculiarities of coping behavior in HIV
infected patients]. Ekologiya cheloveka [Human Ecology], 2010, vol. 4,
pp. 10–15. (in Russ.)
- Neznanov N.G., Khalezova N.B., Khobeish M.A., et al.
Kliniko-neirofiziologicheskie osobennosti psikhicheskikh rasstroistv u bol'nykh
VICh-infektsiei. Obozrenie psikhiatrii i meditsinskoi psikhologii [V.M.
Bekhterev Review of Psychiatry and Medical Psychology], 2018, no. 4., pp.
52–63. doi: 10.31363/2313-7053-2018-4-53-63 (in Russ., abstr. in Engl.)
- Tarabrina N.V. Praktikum po psikhologii posttravmaticheskogo stressa
[Handbook on psychology of posttraumatic stress]. Saint-Petersburg: Piter,
2001. 272 p. (in Russ.)
- Trofimova T.N., Kataeva G.V., Gromova E.A., et al. VICh-assotsiirovannye
neirokognitivnye narusheniya: diagnostika, vyyavlenie prichin i effektivnost'
terapii [HIV-associated neurocognitive disorders: diagnosis, detection of
causes and therapy efficiency]. VICh-infektsiya i immunosupressii [HIV
Infection and Immunosuppressive Disorders], 2018, vol. 10, no. 4, pp. 7–24.
doi: 10.22328/2077-9828-2018-10-4-7-24 (in Russ., abstr. in Engl.).
- Anderson B.A., Kronemer S.I., Rilee J.J., et al. Reward, attention, and
HIV-related risk in HIV+ individuals. Neurobiology of Disease, 2016,
vol. 92 (Part B), pp. 157–165. doi: 10.1016/j.nbd.2015.10.018
- Baddeley A., Emslie H., Kolodny J., et al. Random generation and the
executive control of working memory. Quarterly Journal of Experimental
Psychology, 1998, vol. 51, no. 4, pp. 819–852. doi: 10.1080/713755788
- Barker P.B., Bizzi A., De Stefano N., et al. Clinical MR Spectroscopy:
Techniques and Applications. New York: Cambridge University Press, 2009. 256
p. doi: 10.1017/ cbo9780511770647
- Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical
and powerful approach to multiple testing. Journal of the Royal Statistical
Society, 1995, vol. 57, pp. 289–300.
- Cohen R.A., Siegel S., Gullett J.M., et al. Neural response to working
memory demand predicts neurocognitive deficits in HIV. Journal of
Neurovirology, 2018, vol. 24,
no. 3, pp. 291–304. doi: 10.1007/s13365-017-0607-z
- Derogatis L.R., Cleary P.A. Factorial invariance across gender for the
primary symptom dimension of the SCL-90. British Journal of Social and
Clinical Psychology, 1977, vol. 16, no. 4, pp. 347–356. doi:
10.1111/j.2044-8260.1977.tb00241.x
- Du Plessis S., Vink M., Joska J., et al. HIV infection and the
fronto-striatal system:
a systematic review and meta-analysis of fMRI studies. AIDS, 2014, vol.
28, pp. 803–811. https:.doi.org/10.1097/qad.0000000000000151
- Ellis R.J., Calero P., Stockin M.D. HIV infection and the central nervous
system:
a primer. Neuropsychology Review, 2009, vol. 19, no. 2, pp. 144–151.
doi: 10.1007/s11065-009-9094-1
- Evans A.C., Kamber M., Collins D.L., et al. An MRI-based probabilistic
atlas of neuroanatomy. In S.D. Shorvon, et al (eds.), Magnetic Resonance
Scanning and Epilepsy. New York, NY: Springer, 1994, pp. 263–274. doi:
10.1007/978-1-4615-2546-2_48
- Fornito A., Yücel M., Dean B., et al. Anatomical abnormalities of the
anterior cingulate cortex in schizophrenia: bridging the gap between
neuroimaging and neuropathology. Schizophrenia Bulletin, 2009, vol. 35,
no. 5, pp. 973–993.
doi: 10.1093/schbul/sbn025
- Handbook of Executive function. S. Goldstein, J. Naglieri (eds.). New York:
Springer, 2014. 555 p. doi: 10.1007/978-1-4614-8106-5
- Hazari N., Narayanaswamy J.C, Venkatasubramanian G. Neuroimaging findings
in obsessive–compulsive disorder: A narrative review to elucidate
neurobiological underpinnings. Indian Journal of Psychiatry, 2019, vol.
61, no. 1, pp. 9–29.
doi: 10.4103/psychiatry.IndianJPsychiatry_525_18
- Heaton R.K., Franklin D.R., Ellis R.J., et al. HIV-associated
neurocognitive disorders before and during the era of combination
antiretroviral therapy: differences in rates, nature, and predictors.
Journal of Neurovirology, 2011, vol. 17, no. 1, pp. 3–16.
doi: 10.1007/s13365-010-0006-1
- Hinkin C.H., Castellon S.A., Durvasula R.S., et al. Medication adherence
among HIV+ adults: effects of cognitive dysfunction and regimen complexity.
Neurology, 2002, vol. 59, no. 12, pp. 1944–1950. doi:
10.1212/01.wnl.0000038347.48137.67
- Iudicello J.E., Woods S.P., Weber E., et al. HIV Neurobehavioral Research
Center (HNRC) Group. Cognitive mechanisms of switching in HIV-associated
category fluency deficits. Journal of Clinical and Experimentl
Neuropsycholology, 2008, vol. 30, no. 7,
pp. 797–804. doi: 10.1080/13803390701779578
- Jiang X., Barasky R., Olsen H., et al. Behavioral and neuroimaging evidence
for impaired executive function in "cognitively normal" older HIV-infected
adults. AIDS Care, 2015, vol. 17, pp. 1–5. doi:
10.1080/09540121.2015.1112347
- Kübler A., Dixon V., Garavan H. Automaticity and reestablishment of
executive control-an fMRI study. Journal of Cognitive Neuroscience,
2006, vol. 18, no. 8,
pp. 1331–1342. doi: 10.1162/jocn.2006.18.8.1331
- McDonald J.H. Handbook of Biological Statistics (3rd ed.), Baltimore,
Maryland: Sparky House Publishing, 2014, pp. 254–260. URL:
http://www.biostathandbook.com/ multiplecomparisons.html (Accessed
20.03.2020)
- McIntosh R.С., Rosselli M., Uddina L.Q., et al. Neuropathological sequelae
of Human Immunodeficiency Virus and apathy: A review of neuropsychological and
neuroimaging studies. Neuroscience and Biobehavioral Reviews, 2015, vol.
55, pp. 147–164.
doi: 10.1016/j.neubiorev.2015.04.008
- Owen A.M. Cognitive dysfunction in Parkinson's disease: the role of
frontostriatal circuitry. Neuroscientist, 2004, vol. 6, pp. 525–537.
doi: 10.1177/1073858404266776
- Rosenberg D.R., Mirza Y., Russell A., et al. Reduced anterior
cingulate glutamatergic concentrations in childhood OCD and major depression
versus healthy controls. Journal of American Academy of Child and Adolescent
Psychiatry, 2004, vol. 43,
no. 9, pp. 1146–1153. doi: 10.1097/01.chi.0000132812.44664.2d
- Sacktor N., Lyles R.H., Skolasky R., et al. Multicenter AIDS Cohort Study.
HIV-associated neurologic disease incidence changes. Neurology, 2001,
vol. 56, no. 2,
pp. 257–260. doi: 10.1212/01.wnl.0000397842.06268.c0
- Statistical Parametric Mapping. URL: www.fil.ion.ucl.ac.uk/spm/ (Accessed
12.08.2019).
- Su H., Zuo C., Zhang H., et al. Regional cerebral metabolism alterations
affect resting-state functional connectivity in major depressive disorder.
Quantitative Imaging in Medicine and Surgery, 2018, vol. 8, no. 9, pp.
910–924. doi: 10.21037/qims.2018.10.05
- WFU PickAtlas. URL: http:.www.nitrc.org/projects/wfu_pickatlas/ (Accessed
12.08.2019).
- Woods S.P., Moore D.J., Weber E., et al. Cognitive neuropsychology of
HIV-associated neurocognitive disorders. Neuropsychology Review, 2009,
vol. 19, no. 2, pp. 152–168. doi: 10.1007/s11065-009-9102-5
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