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Psychic State and Cognitive Function in HIV-infected Patients and Functional State of the Brain Structures (According to Positron Emission Tomography and Magnetic Resonance Spectroscopy) 119
Gromova E.A.
PhD in Medicine, Head of the Department, Radiology Department, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0001-7723-8242
e-mail: gromova@ihb.spb.ru Kataeva G.V.
PhD in Biology, Scientific Director, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0003-0463-9832
e-mail: galina@ihb.spb.ru Khomenko I.G.
PhD in Psychology, Researcher, Neuroimaging Laboratory, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0001-7593-499X
e-mail: khomenko@ihb.spb.ru Kotomin I.A.
Engineer, Radiology Department, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0002-8966-4107
e-mail: kotomin@ihb.spb.ru Bogdan A.A.
Junior Researcher of the Laboratory of Stereotactic Methods, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia
ORCID: https://orcid.org/0000-0002-2836-1516
e-mail: andrey@ihb.spb.ru
The article presents the results of the study of cognitive functions and the psychic state of HIV-infected patients. 38 patients aged 25-45 years were examined. In HIV-infected patients, dysfunctions of the central nervous system observed, which could be detected in the early stages after infection. Indicators of cognitive functions and psychic state correlated with the metabolism of the cerebral cortex, mainly with the metabolism of structures associated with executive functions. Obviously, patients of presented category have a decline in executive functions. Therefore, it is important to include psychocorrective treatment aimed at training of emotional-volitional functions, in the rehabilitation program which should also contribute to the improvement of cognitive functions and better social adaptation. The revealed changes in glucose metabolism and the content of N-acetyl aspartate were nonspecific and could be caused by a combination of the direct effect of the virus on the brain tissue, psychogenic and premorbid factors. Most likely, the existing premorbid features enhanced by the toxic effects of HIV and severe psycho-emotional stress associated with obtaining information about infection.
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