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Clinical Psychology and Special Education

Publisher: Moscow State University of Psychology and Education

ISSN (online): 2304-0394

DOI: https://doi.org/10.17759/cpse

License: CC BY-NC 4.0

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Adaptive Status, Autistic Symptoms and Cognitive Profile in Patients with Monogenic Form of Autism Spectrum Disorders – Fragile X Syndrome. 79

Danilina K.K.
Researcher, Research and Clinical Center of Pediatric psychoneurology of Moscow Department of Public Health, Moscow, Russia
ORCID: https://orcid.org/0000-0002-0396-2884
e-mail: d-kk@mail.ru

Gorbachevskaya N.L.
Doctor of Biology, Professor, Head of Research Laboratory, Federal Resource Center for Organization of Comprehensive Support to Children with ASD, Moscow State University of Psychology and Education, Moscow, Russia
ORCID: https://orcid.org/0000-0002-8558-9007
e-mail: gorbachevskaya@yandex.ru

Abstract
The article analyzes psychological data of a large group (55 males and 6 females) of subjects with monogenic form of hereditary cognitive impairment with autistic symptoms – Martin-Bell syndrome (FXS) at different age ranges (from 2 to 34 years old). As a result of the analysis, significant cognitive impairments were identified, which persisted throughout the studied age interval (IQ 50 ± 2.1 in males and 60 ± 5.6 in females). Autistic disorders were observed on average in 60% of subjects (less in females) and were most pronounced at 8-12 years. Use of Autism Diagnostic Observation Scale-2 (ADOS-2) allowed us to show that “Social Affect” scale makes the main contribution to overall score of autistic manifestations. Almost all subjects showed a significantly reduced level of adaptive skills. The lowest scores on “Communication”, “Socialization” and “Everyday life skills” scales were observed at the age of 8-12 years. With increase in age, subjects improved only on “Daily Life Skills” scale. It was also shown that a higher degree of adaptation and better nonverbal intelligence was observed in children with less severe autistic symptoms.

Keywords: mental retardation syndrome linked to fragile X chromosome; autism spectrum disorders; Martin-Bell Syndrome; fragile X syndrome; socialization; nonverbal intelligence, adaptive skills

Column: Empirical research

DOI: https://doi.org/10.17759/cpse.2020090204

For Reference

Funding

this work was supported by RFBR grant № 19-013-00750

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