Modern Approaches to Diagnosis and Treatment of Cognitive Disorders in Children and Adults 1036
Doctor of Biology, Professor, Head of Research Laboratory, Federal Resource Center for Organization of Comprehensive Support to Children with ASD, Moscow State University of Psychology and Education, Moscow, Russia
The article regards etiology and pathogenesis of some inherited mental diseases which are entailed frank cognitive disorders. It describes psychoneurological disorders during diseases such as neurofibromatosis, tuberous sclerosis, X-linked mentally retardation syndrome, Rett's syndrome. Their separation from the group of undifferential forms becomes available with improvement of genetic methods of analysis. Defining genes in which mutations entailed disorders in mental development gives an opportunity to create models of these disorders on animals and study their pathogenesis mechanisms. The article discusses approaches to therapy of cognitive disorders based on understanding of signal pathway functioning. It also presents first results of pathogeneticaly valid therapy.
Keywords: inherited mental diseases, cognitive disorders, pathogenesis, therapy.
Column: Clinical Psychology
Belichenko N. P., Belichenko P.V., Li Vong Hua, Moble W.
C., Frank U. Comparative Study Of Brain Morphology. In Mecp2 Mutant Mouse
Models of Rett Syndrome // The Journal оf Comparative Neurology. 2008.
Ehninger D., de Vries P. J., Silva A. J. From mTOR to
cognition: molecular and cellular mechanisms of cognitive impairments in
tuberous sclerosis // Journal of Intellectual Disability Research. October
2009. Vol. 53.
Sahin A. M. et al. A mouse model of tuberous sclerosis:
neuronal loss of TSC icauses dysplastic and ectopic neurons, reduced
myelination, seizure activity, and limited survival // Journal of
Voinova-Ulas V. Yu., Iourov I. Yu., Gorbachevskaya N. L.,
Boudilov A.V., Demidova I. A., Giunti L., Sorokin A. B., Prassolov V. S.,
Villard L. Towards genotype-phenotype correlationsin Rett syndrome: the study
of MECP2 mutations and X chromosome inactivation // Gene. Brain. Behavior.
Edited by S. B. Malych, A. M. Torgersen. Oslo-Moscow, 2007.
De Vries P. J., Oliver Ch. Intellectual disabilities and
genetic disorders can lead the way in translational research // Journal of
Intellectual Disability Research. October 2009. Vol. 53.