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  Previous issue (2021. Vol. 13, no. 1)

Psychological-Educational Studies

Former Title: Psychological Science and Education

Publisher: Moscow State University of Psychology and Education

ISSN (online): 2587-6139


License: CC BY-NC 4.0

Started in 2009

Published quarterly

Free of fees
Open Access Journal


Genetic Mechanisms of Mental Disturbances: Chromosomal and Genomic Disorders 1240


Yurov I.Yu.
professor , RANH, Moscow, Russia

Vorsanova S.G.
professor, head of laboratory, Institute of pediatrics and pediatric surgery, Rosmedtehnologii, Moscow, Russia

Yurov Yu.B.
professor, head of laboratory at the Research center of mental health. Leading researcher of the scientific and educational center “Neurobiological diagnosis of hereditary diseases in children and adolescents”, Moscow State University of Psychology and Education, Moscow, Russia

Currently, it is well known that genetic anomalies significantly contribute to pathogenesis of different mental disturbances, including such diseases as mental retardation, autism, schizophrenia and Alzheimer’s disease. More precisely, up to 50% of cases of these diseases can be associated with gene, chromosomal and genomic mutations. In this context, providing for medical and psychological help at modern level for individuals affected by these diseases would be incomplete without application of newly introduced methods for genome analysis to diagnose and to identify mechanisms of neuropsychiatric disorders. Here, a brief overview of current advances in analyses of genetic mechanisms of mental disturbances and developments in diagnosis of chromosomal and genomic disorders are given.

Keywords: autism, Alzheimer’s disease, genome, DNA, mental retardation, chromosomal abnormalities, schizophrenia.

Column: Clinical Psychology

For Reference

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  2. Vorsanova S. G. i dr. Citogeneticheskie, molekuljarno-citogeneticheskie i kliniko-genealogicheskie issledovanija materej detej s autizmom: poisk semejnyh geneticheskih markerov autisticheskih rasstrojstv. // Zhurn. nevrol. psihiat. 2009. T. 109. № 6.
  3. Jurov I. Ju., Vorsanova V. G., Jurov Ju. B. Psihiatricheskaja genetika: teorija i praktika // Psihicheskoe zdorov'e. 2006. № 3.
  4. Jurov I. Ju., Vorsanova S. G., Jurov Ju. B. Molekuljarnaja nejrocitogenetika: nestabil'nost' genoma v mozge pri psihicheskih zabolevanijah // Psihiatrija. 2007. № 4 (28).
  5. Iourov I. Y. et al. Aneuploidy in the normal, Alzheimer’s disease and ataxia-telangiectasia brain: differential expression and pathological meaning // Neurobiol. Dis. 2009. V. 34. № 2.
  6. Iourov I. Y., et al. Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain // Hum. Mol. Genet. 2009. V.18. № 14.
  7. Iourov I. Y., Vorsanova S. G., Yurov Y. B. Chromosomal variation in mammalian neuronal cells: known facts and attractive hypotheses // Int. Rev. Cytol. 2006. V. 249.
  8. Iourov I. Y., Vorsanova S. G., Yurov Y. B. Intercellular genomic (chromosomal) variations resulting in somatic mosaicism: mechanisms and consequences // Curr. Genomics. 2006. V. 7. I. 7.
  9. Iourov I. Y., Vorsanova S. G., Yurov Y. B. Molecular cytogenetics and cytogenomics of brain diseases // Curr. Genomics. 2008. V. 9. № 7.
  10. Plomin R., McGuffin P. Psychopathology in the postgenomic era //Annu. Rev. Psychol. 2003. V. 54.
  11. Szatmari P., White J., Merikangas K.R. The use of genetic epidemiology to guide classification in child and adult psychopathology // Int. Rev. Psychiat. 2007. V. 19. № 5.
  12. Vorsanova S. G. et al. Variability in the heterochromatin regions of the chromosomes and chromosomal anomalies in children with autism: identification of genetic markers of autistic spectrum disorders // Neurosci. Behav. Physiol. 2007. V. 37. № 6.
  13. Yurov Y. B. et al. The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1 // Schizophr. Res. 2008. V. 98. № 1 3.
  14. Yurov Y. B. et al. Unexplained autism is frequently associated with low-level mosaic aneuploidy // Journ. Med. Genet. 2007. V. 44. № 8.

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