Influence of Midlands as a Means of Strengthening Immunity in Children with Autism Spectrum Disorders

353

Abstract

The cross-over effect of the influence of the hypoxic environment and physical activity, designated as “cross-adaptation”, on the health promotion of children with autism spectrum disorders (ASD) was investigated. A model has been developed for correcting the health of children with ASD on the basis of systematic seasonal 10-day physical training courses in a natural moderately hypoxic environment. Systematic health improvement courses with the use of special physical exercises in conditions of natural mountain hypoxia develop cellular and humoral mechanisms of immune responses, increase immunity, improve the physical and psycho-emotional state of children. Among 50 young and adolescent children diagnosed with ASD, after 4 10-day health improvement courses during the year, 20% of young children and 80% of adolescents showed an increase in the activity of cellular and humoral immunity. The proposed model for correcting the health of children with ASD is a promising universal non-drug way to increase immunity, stimulate the processes of adaptation and socialization of children with ASD. In the opinion of parents, after health improvement courses, many children have a desire to communicate with both parents and other children.

General Information

Keywords: autism, physical activity, hypoxia, recovery, immunity

Journal rubric: Research & Diagnosis of ASD

Article type: scientific article

DOI: https://doi.org/10.17759/autdd.2020180405

Funding. This work was carried out within the framework of Subproject №APP-IIC-18 / 069P “Inclusive Tourism Product with Rehabilitation for Autistic Children”, funded under the Project “Fostering Productive Innovation”, supported by the World Bank and the Government of the Republic of Kazakhstan. Statements may not reflect the official position of the World Bank and the Government of the Republic of Kazakhstan

Acknowledgements. We express our sincere gratitude for the assistance of the World Bank in Kazakhstan and the group of SUE staff under the leadership of M.M. Sartbaev

For citation: Kapysheva U.N., Karatai Z.K., Bakhtiyarova S.K., Zhaksymov B.I. Influence of Midlands as a Means of Strengthening Immunity in Children with Autism Spectrum Disorders. Autizm i narusheniya razvitiya = Autism and Developmental Disorders, 2020. Vol. 18, no. 4, pp. 43–51. DOI: 10.17759/autdd.2020180405. (In Russ., аbstr. in Engl.)

References

  1. Agadzhanyan N.A., Chizhov A.Ya. Klassifikatsii gipoksicheskikh, gipo- i giperkapnicheskikh sostoyanii [Classifications of hypoxic, hypo- and hypercapnic conditions]. Fiziologichnyi zhurnal [Physiological Journal (Ukraine)], 2003, vol. 49, no. 3, pp. 11—16.
  2. Androsova L.V., Simashkova N.V., Zozulya S.A., Otman I.N., Shushpanova O.V., Makarova L.O., Klyushnik T.P. Vospalitel’nye i autoimmunnye markery rasstroistv autisticheskogo spektra u detei [Inflammatory and autoimmune markers of autism spectrum disorders in children]. Sibirskii vestnik psikhiatrii i narkologii [Siberian Psychiatry and Narcology Herald], 2016, no. 2 (91), pp. 5—9.
  3. Antipova E.I., Nagaeva I.A. Voprosy korrektsii i adaptatsii detei s autizmom [Questions of correction for children with autism]. Sovremennye tendentsii razvitiya nauki i tekhnologii [Contemporary tendencies in the development of science and technology], 2015, no. 7—9, pp. 63—66.
  4. Artemova E.E., Belosvetova D.E. Primenenie art-terapevticheskikh metodov v rabote po formirovaniyu kommunikativnykh navykov u detei s rasstroistvami autisticheskogo spektra [The Use of Art-Therapeutic Methods in the Work on the Formation of Communication Skills in Children With Autism Spectrum Disorders]. Autizm i narusheniya razvitiya [Autism and developmental disorders (Russia)], 2019, vol. 17, no. 4, pp. 35—42. DOI:10.17759/autdd.2019170405
  5. Baimurodov R.S., Amonov M.Yu. Ippoterapiya kak metod lechebnoi fizicheskoi kul’tury (obzor literatury) [Hippotherapy as method of medical physical culture (review of literature)]. Biologiya i integrativnaya meditsina [Biology and integrative medicine], 2017, no. 3, pp. 217—242.
  6. Valishin E.Kh. Adaptivnaya fizicheskaya kul’tura dlya detei s autizmom sredstvami ABA-terapii [Adaptive physical education for children with autism by means of ABA therapy]. In Mokeev G.I. (ed.) Aktual’nye problemy fizicheskoi kul’tury, sporta i turizma: materialy XII Mezhdunarodnoi nauchno-prakticheskoi konferentsii [Actual problems of physical culture, sports and tourism: proceedings of the 12th international scientific and practical conference]. Ufa: Publ. Ufa State Aviation Technical University, 2018. Pp. 465—467. ISBN 978-5-4221-1103-9.
  7. Gabysheva V.A. «Telesnyi intellekt»: unikal’naya metodika vosstanovleniya detskogo zdorov’ya [“Body intellect”: the unique methodic for restoring a child’s health]. In Barabanov R.E. (ed.) Innovatsionnye metody diagnostiki, lecheniya i reabilitatsii detei i podrostkov s narusheniyami razvitiya: sbornik statei po materialam I Vserossiiskoi s mezhdunarodnym uchastiem nauchno-prakticheskoi konferentsii (g. Moskva, 29 noyabrya 2019 g.) [Innovative methods for diagnostic, treating and rehabilitating children and adolescents with developmental disorders: proceedings of the 1st national conference with international participation (Moscow, 29 November 2019)]. Moscow: Publ. Moscow University of Technology and Information, 2020. Pp. 38—44.
  8. Grachev V.I., Marinkin I.O., Sevryukov I.T. Vliyanie gipoksii na tsentral’nuyu nervnuyu sistemu, organy i tkani s uchetom vozrastnykh osobennostei [The influence of hypoxia on the central nervous system, organs and fabrics in accordance with age specialities]. Norwegian Journal of Development of the International Science, 2018, no. 19-2, pp. 3—20. ISSN 3453-9875.
  9. Dokukina I.A. Korrektsiya agressivnogo povedeniya trudnykh podrostkov metodom ippoterapii [Correcting problem teenagers’ aggressive behavior by means of hippotherapy]. In Antonov A.I. (ed.) Semeino-detnyi obraz zhizni v sotsiologicheskom izmerenii: Materialy vebinara MGU imeni M.V. Lomonosova, sotsiologicheskii fakul’tet [The ‘family- children’ way of life in the sociological measurement: Proceedings of the Moscow State University webinar (faculty of sociology)]. Moscow: Publ. MaksPress, 2018. Pp. 42—46. ISBN 978-5-317-06002-2.
  10. Zabozlaeva I.V., Malinina E.V., Teleshova L.F., Nikushkina K.V., Orner I.Yu. Pokazateli sostoyaniya immunnoi sistemy u detei s rasstroistvami autisticheskogo spektra [Indicators of immune system in children with autism spectrum disorders]. Rossiiskii immunologicheskii zhurnal [Russian Journal of Immunology], 2016, vol. 10 (19), no. 3, pp. 262—264.
  11. Kaladze N.N., Nuvoli A.V. Korrektsiya neirotransmitternogo mekhanizma tsirkadiannogo ritma u detei s autizmom metodom del’finoterapii [Correcting the neurotransmitter mechanism of the circadian rhythm in autistic children by means of dolphin assisted therapy]. Vestnik vosstanovitel’noi meditsiny [Rehabilitation Medicine Herald], 2016, no. 6,  pp. 17—21.
  12. Krishtal’ (Slepyan) M. Oda fizkul’ture, ili Pochemu sport neobkhodim v kompleksnoi programme zanyatii dlya rebenka s autizmom [Ode to Physical Education, or Why Sports are Necessary in a Comprehensive Program for Children with Autism]. Autizm i narusheniya razvitiya [Autism and developmental disorders (Russia)], 2018, vol. 16, no 1, pp. 61—68. DOI:10.17759/autdd.2018160109
  13. Libling M.M. Korrektsiya detskogo autizma s pomoshch’yu igrovoi kholding-terapii [Correcting autism in children with the aid of playful holding therapy]. Vospitanie i obuchenie detei s narusheniyami razvitiya [Raising and teaching children with developmental disorders], 2014, no. 7, pp. 6—12.
  14. Nikolaeva A.G. Ispol’zovanie adaptatsii k gipoksii v meditsine i sporte [Uses of adaptation to hypoxia in medicine and sports]. Vitebsk: Publ. Vitebsk State Medical University, 2015. 150 p. ISBN 978-985-466-769-0.
  15. Sepiashvili R.I. Fiziologiya immunnoi sistemy [Physiology of the immune system]. Moscow: Publ. Meditsina-Zdorov’e, 2015. 328 p.
  16. Chaliev A.A., Ovcharov A.O. Statistika: Uchebno-metodicheskoe posobie. Chast’ 1 [Statistics: learning guide. Part 1]. Nizhnii Novgorod: Publ. State University of Nizhnii Novgorod, 2007. 87 p.
  17. Bouslama M., Adla-Biassette H., Ramanantsoa N., Bourgeois T., Bollen B., Brissaud O. et al. Protective effects of intermittent hypoxia on brain and memory in a mouse model of apnea of prematurity. Frontiers in Physiology, 2015, vol. 6, p. 313. DOI:10.3389/fphys.2015.00313
  18. Careaga M., van de Water J., Ashwood P. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics, 2010, vol. 7, no. 3, pp. 283—292. pmid:20643381 DOI:10.1016/j.nurt.2010.05.003
  19. Coury D.L., Ashwood P., Fasano A., Fuchs G., Geraghty M. et al. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics, 2012, vol. 130, no. Supplement 2, pp. S160—S168. DOI:10.1542/ peds.2012-0900N
  20. Gandal M.J., Haney J.R., Parikshak N.N., Leppa V., Ramaswami G. et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science, 2018, vol. 359, no. 6376, pp. 693—697. DOI:10.1126/science.Aad6469
  21. Viscor G., Torella J.R., Corral L., Ricart A. et al. Physiological and biological responses to short-term intermittent hypobaric hypoxia exposure: from sports and mountain medicine to new biomedical applications. Frontiers in psychology, 2018, vol. 9, p.  814. DOI:10.3389/fphys.2018.00814
  22. Iadarola S., Levato L., Harrison B., Smith T., Lecavalier L. et al. Teaching parents behavioral strategies for autism spectrum disorder (ASD): effects on stress, strain, and competence. Journal of autism and Developmental Disorders, 2018, vol. 48, no. 4, pp. 1031—1040.  DOI:10.1007/s10803-017-3339-2
  23. Pangrazzi L., Balasco L., Bozzi Y. Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders.
  24. International Journal of Molecular Sciences, 2020, vol.20, no. 19, p. 3293. DOI:10.3390/ijms21093293
  25. Onore C., Careaga M., Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain, Behavior, and Immunity, 2012, vol. 26, no. 3, pp. 383—392. pmid:21906670  DOI:10.1016/j.bbi.2011.08.007
  26. Ross H.H., Sandhu M.S., Cheung T.F., Fitzpatrick G.M., Sher W.J. et al. In vivo intermittent hypoxia elicits enhanced expansion and neuronal differentiation in cultured neural progenitors. Experimental Neurology, 2012, vol. 235, no. 1, pp.  238—245. DOI:10.1016/j.expneurol.2012.01.027
  27. Sanchez A.M.J., Borrani F. Effects of intermittent hypoxic training performed at high hypoxia level on exercise performance in highly trained runners. Journal of Sports Sciences, 2018, vol. 36, no. 18, pp. 2045—2052. DOI:10.1080/02640414.2018.1434747
  28. Wang L.W., Tancredi D.J., Thomas D.W. The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. Journal of Developmental and Behavioral Pediatrics, 2011, vol. 32, no. 5, pp. 351—360. pmid:21555957 DOI:10.1097/DBP.0b013e31821bd06a

Information About the Authors

Unzira N. Kapysheva, Professor, RSE “Institute of Human and Animal Physiology” SC MES RK, Almaty, Kazakhstan, ORCID: https://orcid.org/0000-0001-9162-5281, e-mail: unzira@inbox.ru

Zhanat K. Karatai, Director, «Ski Park Pioneer» LLP, Almaty, Kazakhstan, ORCID: https://orcid.org/0000-0002-1259-3670, e-mail: zhanna.karatai@mail.ru

Sholpan K. Bakhtiyarova, Head of Laboratory "Ecological physiology", Republican State Enterprise "Institute of Human and Animal Physiology" Committee of Science of the Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Kazakhstan, ORCID: https://orcid.org/0000-0002-6434-0130, e-mail: bifara.66@mail.ru

Balatbek I. Zhaksymov, Master of Science, Institute of Human and Animal Physiology, Almaty, Kazakhstan, ORCID: https://orcid.org/0000-0003-4116-5779, e-mail: bolat_kaz@inbox.ru

Metrics

Views

Total: 1065
Previous month: 33
Current month: 12

Downloads

Total: 353
Previous month: 3
Current month: 1