Risk Factors and Chronicity of Bipolar Affective Disorder: Biological and Psychosocial Aspects

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Abstract

The literature review provides the results of epidemiological studies of bipolar affective disorder (BAD). Biological risk factors and adverse course of BAD are considered in detail, including genetic ones (BAD is defined as a genetically determined disorder that has common non-specific genetic risk factors with depressive and schizophrenic spectrum disorders). We address the data on various neurotransmitter systems dysfunctions that may play a role in the pathogenesis of the disease. The results of studies of biological markers in the blood, as well as morphological disorders in brain structures, are analyzed. Stressful situations, that can aggravate manifestations of a genetic and biochemical predisposition, disturbances in emotional and cognitive mental processes, neurocognitive deficiency, and dysfunctional family relationships are considered as psychosocial factors of BAD.

General Information

Keywords: bipolar affective disorder (BAD), psychosocial factors of BAD, biological factors of BAD

Journal rubric: Research Reviews

Article type: review article

DOI: https://doi.org/10.17759/cpp.2019270406

For citation: Dovzhenko T.V., Tsarenko D.M., Yudeeva T.Y. Risk Factors and Chronicity of Bipolar Affective Disorder: Biological and Psychosocial Aspects. Konsul'tativnaya psikhologiya i psikhoterapiya = Counseling Psychology and Psychotherapy, 2019. Vol. 27, no. 4, pp. 81–97. DOI: 10.17759/cpp.2019270406. (In Russ., аbstr. in Engl.)

References

 

Information About the Authors

Tatyana V. Dovzhenko, Doctor of Medicine, Professor, Chief Researcher, Laboratory of Psychological Counseling and Psychotherapy, Moscow Research Institute of Psychiatry - Federal Budgetary Institution "V. Serbsky National Medical Research Centre for Psychiatry and Narcology" of the Ministry of Health of Russia, Moscow, Russia, e-mail: dtv99@mail.ru

Dmitry M. Tsarenko, PhD in Medicine, senior researcher, Laboratory of Psychological Counseling and Psychotherapy, Moscow Research Institute of Psychiatry— Branch of The Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, e-mail: dropship@rambler.ru

Tatianaatiana Y. Yudeeva, PhD in Psychology, Associate Professor, Senior Researcher, Laboratory of Psychological Counseling and Psychotherapy, Moscow Research Institute of Psychiatry — Branch of The Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, e-mail: tatiana.yudeeva@yandex.ru

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