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Counseling Psychology and Psychotherapy
2019. Vol. 27, no. 4, 81–97
https://doi.org/10.17759/cpp.2019270406
ISSN: 2075-3470 / 2311-9446 (online)

Risk Factors and Chronicity of Bipolar Affective Disorder: Biological and Psychosocial Aspects

 
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Abstract

The literature review provides the results of epidemiological studies of bipolar affective disorder (BAD). Biological risk factors and adverse course of BAD are considered in detail, including genetic ones (BAD is defined as a genetically determined disorder that has common non-specific genetic risk factors with depressive and schizophrenic spectrum disorders). We address the data on various neurotransmitter systems dysfunctions that may play a role in the pathogenesis of the disease. The results of studies of biological markers in the blood, as well as morphological disorders in brain structures, are analyzed. Stressful situations, that can aggravate manifestations of a genetic and biochemical predisposition, disturbances in emotional and cognitive mental processes, neurocognitive deficiency, and dysfunctional family relationships are considered as psychosocial factors of BAD.

General Information

Keywords: bipolar affective disorder (BAD), psychosocial factors of BAD, biological factors of BAD

Journal rubric: Research Reviews

OpenAlex citations: 1

OpenAlex topics: Bipolar Disorder and Treatment, Tryptophan and brain disorders, Schizophrenia research and treatment

Information about the work in OpenAlex

Number of citations: 1

Topics

Bipolar Disorder and Treatment

This cluster of papers covers a wide range of topics related to bipolar disorder, including prevalence, natural history, neurobiology, genetics, cognitive function, treatment guidelines, neuroimaging findings, suicide risk, inflammation, and medication effects. The papers provide insights into the epidemiology and management of bipolar disorder.

Number of works: 64388  |  Total number of citations: 1329584

Topic detailsв OpenAlex

Tryptophan and brain disorders

This cluster of papers explores the intricate relationship between the immune system and the brain, focusing on neuroinflammation, cytokine signaling, and the impact of immune activation on psychiatric disorders such as depression and schizophrenia. The role of tryptophan metabolism, oxidative stress, and maternal immune activation in influencing brain function and behavior is also a key area of investigation.

Number of works: 65392  |  Total number of citations: 1496138

Topic detailsв OpenAlex

Schizophrenia research and treatment

This cluster of papers focuses on the research, treatment, and various aspects of schizophrenia, including the effectiveness of antipsychotic drugs, neurocognitive deficits, genetic association studies, metabolic syndrome, neurodevelopmental models, cognitive therapy, social cognition, prodromal symptoms, dopamine dysfunction, and neuroanatomical abnormalities in individuals with schizophrenia.

Number of works: 141014  |  Total number of citations: 3403879

Topic detailsв OpenAlex

Work details in OpenAlex

Article type: review article

DOI: https://doi.org/10.17759/cpp.2019270406

Published

For citation: Dovzhenko, T.V., Tsarenko, D.M., Yudeeva, T.Y. (2019). Risk Factors and Chronicity of Bipolar Affective Disorder: Biological and Psychosocial Aspects. Counseling Psychology and Psychotherapy, 27(4), 81–97. (In Russ.). https://doi.org/10.17759/cpp.2019270406

© Dovzhenko T.V., Tsarenko D.M., Yudeeva T.Y., 2019

License: CC BY-NC 4.0

References

 

Information About the Authors

Tatyana V. Dovzhenko, Doctor of Medicine, Professor, Chief Researcher, Laboratory of Psychological Counseling and Psychotherapy, Moscow Research Institute of Psychiatry - Federal Budgetary Institution "V. Serbsky National Medical Research Centre for Psychiatry and Narcology" of the Ministry of Health of Russia, Moscow, Russian Federation, ORCID: https://orcid.org/0000-0002-5456-2573, e-mail: dtv99@mail.ru

Dmitry M. Tsarenko, Candidate of Science (Medicine), senior researcher, Laboratory of Psychological Counseling and Psychotherapy, Moscow Research Institute of Psychiatry— Branch of The Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russian Federation, ORCID: https://orcid.org/0000-0003-1160-2755, e-mail: dropship@rambler.ru

Tatianaatiana Y. Yudeeva, Candidate of Science (Psychology), Associate Professor, Senior Researcher, Laboratory of Psychological Counseling and Psychotherapy, Moscow Research Institute of Psychiatry — Branch of The Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russian Federation, ORCID: https://orcid.org/0000-0002-4981-3171, e-mail: tatiana.yudeeva@yandex.ru

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