Illness Representations and Treatment Adherence in Patients with Acute Leukemia and Lymphoma

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Abstract

This study aims to investigate the relationship between of perceptions of illness and its causes, body and health, and illness behavior in relation to treatment adherence in patients with acute leukemia and lymphoma. We present one empirical study involving lymphoma patients (N=58) aged 19 to 64 years (M=41.22; SD=11.17), of whom 70.7% were female, and acute leukemia patients (N=51) aged 18 to 64 years (M=35.12; SD=12.90), of whom 54.9% were female. Participants completed the Illness Perception Questionnaire-Revised (IPQ-R), the Cognitions about body and health questionnaire (CABAH), the Scale for the Assessment of Illness Behavior (SAIB) and 4-item Morisky Medication Adherence Scale. The results suggest that patients with lymphoma are at risk for decreased treatment adherence compared to patients with acute leukemia. In acute leukemia, the targets of psychological work aimed at preventing reduced adherence to treatment are patients' perceptions of the psychological causes of the disease and their belief that healthy habits are not important for maintaining health, while in patients with lymphomas — uncertainty that immune problems could provoke the disease.

General Information

Keywords: treatment adherence, illness beliefs, illness perceptions, acute leukemia, lymphoma, illness behavior, body and health beliefs

Journal rubric: Empirical Research

Article type: scientific article

DOI: https://doi.org/10.17759/cpse.2024130106

Funding. The authors declare the absence of external funding for the research and publication of the article.

Acknowledgements. No

Received: 17.12.2023

Accepted:

For citation: Esina L.V., Vybornykh D.E., Rasskazova E.I., Gemdzhian E.G., Zvonkov E.E., Lukyanova I.A., Moiseeva T.N., Magomedova A.U. Illness Representations and Treatment Adherence in Patients with Acute Leukemia and Lymphoma [Elektronnyi resurs]. Klinicheskaia i spetsial'naia psikhologiia = Clinical Psychology and Special Education, 2024. Vol. 13, no. 1, pp. 87–104. DOI: 10.17759/cpse.2024130106. (In Russ., аbstr. in Engl.)

References

  1. Vybornykh D.E. Vliyanie psikhotropnykh preparatov na sistemu krovetvoreniya [The effect of psychotropic drugs on the hematopoietic system]. Sotsial'naya i klinicheskaya psikhiatriya = Social and Clinical Psychiatry, Vol. 12, no. 4, pp. 71–79. (In Russ.)
  2. Kol'gaeva E.I., Drokov M. Yu., Vybornykh D. E. Priverzhennost' k lecheniyu u patsientov s zabolevaniyami sistemy krovi i retsipientov allogennykh organov i tkanei [Treatment adherence in patients with blood system diseases and recipients of allogeneic organs and tissues]. Onkogematologiya = Oncogematology, 2023. Vol. 18, no. 1, pp. 132–141. DOI: 10.17650/ 1818‑8346‑2023‑18‑1‑132‑141(In Russ., abstr. in Engl.)
  3. Rasskazova E.I. Kliniko-psikhologicheskii podkhod k diagnostike trudnokvalifitsiruemykh simptomov v ramkakh somatoformnykh rasstroistv [Clinical and psychological approach to the diagnosis of difficult-to-qualify symptoms within somatoform disorders]. Obozrenie psikhiatrii i meditsinskoi psikhologii im. V.M. Bekhtereva = V.M. Bekhterev review of psychiatry and medical psychology, 2013. Vol. 3, pp. 25–32. (In Russ., abstr. in Engl.)
  4. Rasskazova E.I. Ponyatie samoregulyatsii v psikhologii zdorov'ya: novyi podkhod ili oblast' primeneniya? [The concept of self-regulation in health psychology: a new approach or a sphere of application?]. Teoreticheskaja i jeksperimental'naja psihologija = Theoretic and Experimental Psychology, No. 1, pp. 43–56. (In Russ., abstr. in Engl.)
  5. Rasskazova E.I. Russkoyazychnaya aprobatsiya oprosnika vospriyatiya bolezni R. Moss-Morris i dr.: aprobatsiya na vyborke bol'nykh s nepsikhoticheskimi depressiyami [Russian-language approbation of the illness perception questionnaire R. Moss-Morris et al.: approbation on a sample of patients with non-psychotic depression]. Vestnik Moskovskogo universiteta. Seriya 14. Psikhologiya = Moscow University Psychology Bulletin. Series 14. Psychology, No. 1, pp. 123–142. (In Russ., abstr. in Engl.)
  6. Alaggio R., Amador C., Anagnostopoulos I. et al. The 5th edition of the World Health Organization Classification of haematolymphoid tumours: Lymphoid neoplasms. Leukemia, 2022. Vol. 36 (7), pp. 1720–1748. DOI: 10.1038/s41375-022-01620-2
  7. Bouwman L., Eeltink C.M., Visser O. et al. Prevalence and associated factors of medication non-adherence in hematological-oncological patients in their home situation. BMC Cancer, 2017. Vol. 17 (1), pp. 739. DOI: 10.1186/s12885-017-3735-1
  8. Brown M.T., Bussell J., Dutta S. et al. Medication adherence: Truth and consequences. The American Journal of the Medical Sciences, 2016. Vol. 351 (4), pp. 387–399. DOI: 10.1016/j.amjms.2016.01.010
  9. Foulon V., Schöffski P., Wolter P. Patient adherence to oral anticancer drugs: An emerging issue in modern oncology. Acta Clinica Belgica, Vol. 66 (2), pp. 85–96. DOI: 10.2143/ACB.66.2.2062525
  10. Gil-Guillen V.F., Balsa A., Bernardez B. et al. Medication non-adherence in rheumatology, oncology and cardiology: A review of the literature of risk factors and potential interventions. International Journal of Environmental Research and Public Health, 2022. Vol. 19 (19), e12036. DOI: 10.3390/ijerph191912036
  11. Hall A.E., Paul C., Bryant J. et al. To adhere or not to adhere: Rates and reasons of medication adherence in hematological cancer patients. Critical Reviews in Oncology/Hematology, 2016. Vol. 97, pp. 247–262. DOI: 10.1016/j.critrevonc.2015.08.025
  12. Horne R., Weinman J., Barber N. et al. Concordance, adherence and compliance in medicine taking. London: National Co-ordinating Centre for NHS Service Delivery and Organisation, 2005. 309 p.
  13. Khrushchev S., Vybornykh D., Rasskazova E. et al. Decision making and illness perception contribution to the quality of life in leukemia. Psycho-Oncology, 2018. Vol. 27, no. S3, pp. 206.
  14. Leventhal H., Brissette I., Leventhal E. The common-sense model of self-regulation of health and illness. The self-regulation of health and illness behavior. L.D. Cameron, H. Leventhal (Eds.). London, New York: Routledge, 2003. Pp. 42–65.
  15. Morisky D.E., Green L.W., Levine D.M. Concurrent and predictive validity of a self-reported measure of medication adherence. Medical Care, 1986. Vol. 24 (1), pp. 67–74. DOI: 10.1097/00005650-198601000-00007
  16. Moss-Morris R., Weinman J., Petrie K. et al. The Illness-Revised Perception Questionnaire (IPQ-R). Psychology and Health, 2002. Vol.17(1), pp. 1–16. DOI: 10.1080/08870440290001494
  17. Rief W, Hiller W. A new approach to the assessment of the treatment effects of somatoform disorders. Psychosomatics, 2003. Vol.44(6), pp. 492–498. DOI: 10.1176/appi.psy.44.6.492
  18. Rief W., Hiller W., Margraf J. Cognitive aspects of hypochondriasis and the somatization syndrome. Journal of Abnormal Psychology, 1998. Vol.107(4), pp. 587–595. DOI: 10.1037//0021-843x.107.4.587
  19. Rief W., Ihle D., Pilger F. A new approach to assess illness behaviour. Journal of Psychosomatic Research, 2003. Vol.54 (5), pp. 405–414. DOI: 10.1016/s0022-3999(02)00401-4
  20. Sováriová Soósová M., Suchanova R., Parova V. et al. Association Between Illness Perception and Adherence to Treatment in Slovak Patients with Hypertension: A Cross-sectional Study. The Journal of Cardiovascular Nursing, 2023. Vol. 38 (5), pp. 433–442. DOI: 10.1097/JCN.0000000000000913
  21. Stemler J., Mellinghoff S.C., Khodamoradi Y. et al. Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO). The Journal of Antimicrobial Chemotherapy, Vol. 78 (8), pp. 1813–1826. DOI: 10.1093/jac/dkad143
  22. Svarstad B.L., Chewning B.A., Sleath B.L., Claesson C. The Brief Medication Questionnaire: a tool for screening patient adherence and barriers to adherence. Patient Education and Counseling, 1999. Vol.37(2), pp. 113–124. DOI: 10.1016/s0738-3991(98)00107-4
  23. Zhao M., Zhao J., Chen J. et al. The relationship between medication adherence and illness perception in breast cancer patients with adjuvant endocrine therapy: Beliefs about medicines as mediators. Supportive Care in Cancer, 2022. Vol. 30 (12), pp. 10009–10017. DOI: 10.1007/s00520-022-07411-w"2-07411-w

Information About the Authors

Liubov V. Esina, Assistant at the Department of Pedagogy and Medical Psychology of Institute of Psychological and Social Work, I..M. Sechenov First Moscow State Medical University (Sechenov University), Medical psychologist of the Laboratory for the Study of Mental and Neurological Disorders in Diseases of the Blood System, The NMRC for Hematology, Moscow, Russia, ORCID: https://orcid.org/0000-0001-7253-5694, e-mail: esina.lv@mail.ru

Dmitriy E. Vybornykh, Doctor of Medicine, The Head of the Laboratory for the Study of Mental and Neurological Disorders in Diseases of the Blood System, The National Medical Research Centre for Haematology, Moscow, Russia, ORCID: https://orcid.org/0000-0001-7506-4947, e-mail: dvyb@yandex.ru

Elena I. Rasskazova, PhD in Psychology, Associate Professor, Department of Neuro- and Patopsychology, Lomonosov Moscow State University, Senior Researcher,Mental Health Research Center, Senior Researcher, International Laboratory of Positive Psychology of Personality and Motivation, Higher School of Economics, Moscow, Russia, ORCID: https://orcid.org/0000-0002-9648-5238, e-mail: e.i.rasskazova@gmail.com

Eduard G. Gemdzhian, Biostatistician of the Laboratory for the Study of Mental and Neurological Disorders in Diseases of the Blood System, The NMRC for Hematology, Moscow, Russia, ORCID: https://orcid.org/0000-0002-8357-977X, e-mail: edstat@mail.ru

Еvgeny E. Zvonkov, Doctor of Medicine, Head of the Division of Lymphoproliferative Diseases, The NMRC for Hematology, Moscow, Russia, ORCID: https://orcid.org/0000-0002-2639-7419, e-mail: dr.zvonkov@gmail.com

Irina A. Lukyanova, PhD in Medicine, Head of the Day Hospital of Oncology and Chemotherapy of Hemoblastosis and Hematopoietic Depressions, The NMRC for Hematology, Moscow, Russia, ORCID: https://orcid.org/0000-0002-8337-2242, e-mail: Irina.Donskova99@mail.ru

Tatiana N. Moiseeva, PhD in Medicine, Head of the Clinical and Diagnostic Department of Hematology and Chemotherapy with Day Hospital, The NMRC for Hematology, Moscow, Russia, ORCID: https://orcid.org/0000-0001-9591-8508, e-mail: taniamoiseeva@mail.ru

Aminat U. Magomedova, Doctor of Medicine, Hemаtologist of the Department of Chemotherapy of Lymphatic Tumors with Bone Marrow and Hematopoietic Stem Cell Transplantation Unit with Day Hospital, The NMRC for Hematology, Moscow, Russia, ORCID: https://orcid.org/0000-0003-4263-8275, e-mail: maminat@mail.ru

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