Clinical Psychology and Special Education
2025. Vol. 14, no. 1, 84–94
doi:10.17759/cpse.2025140105
ISSN: 2304-0394 (online)
Cognitive functions in school-age children survived cerebellar tumor
Abstract
Context and relevance. Cerebellar tumors often negatively affect cognitive development and learning abilities in children. Objective. The aim of the current study was to assess the impact of cerebellar cancer on the cognitive functions such as attention, visual-spatial memory, and planning in children. Methods and materials. A total of 322 children (8–17 y.o.), 118 of whom survived cerebellar tumors, participated in the study. Cognitive tasks were assessed using CANTAB. Results. We observed less abilities in attention and working memory and described clinical factors which influenced to performance of school-age children after treatment. Conclusions. Our findings emphasize the necessity of considering these deficits in cerebellar tumor survivors when designing rehabilitation protocols.
General Information
Keywords: cognitive functions, cerebellum, working memory, planning, attention, CANTAB
Journal rubric: Empirical Research
Article type: scientific article
DOI: https://doi.org/10.17759/cpse.2025140105
Acknowledgements. The authors would like to express their gratitude to the head of the Clinical Rehabilitation Research Center "Russkoe pole" Alexander Karelin for supporting this study.
Received 06.10.2024
Accepted
Published
For citation: Mironets, S.A., Deviaterikova, A.A., Shurupova, M.A., Malykh, S.B. (2025). Cognitive functions in school-age children survived cerebellar tumor. Clinical Psychology and Special Education, 14(1), 84–94. (In Russ.). https://doi.org/10.17759/cpse.2025140105
© Mironets S.A., Deviaterikova A.A., Shurupova M.A., Malykh S.B., 2025
License: CC BY-NC 4.0
References
- Cámara, S., Fournier, M. C., Cordero, P., Melero, J., Robles, F., Esteso, B., Vara, M.T., Rodríguez, S., Lassaletta, Á., Budke, M. (2020). Neuropsychological profile in children with posterior fossa tumors with or without postoperative Cerebellar Mutism Syndrome (CMS). Cerebellum (London, England), 19(1), 78—88. https://doi.org/10.1007/s12311-019-01088-4
- Chieffo, D.P.R., Lino, F., Arcangeli, V., Moriconi, F., Frassanito, P., Massimi, L., Tamburrini, G. (2022). Posterior fossa tumor rehabilitation: an up-to-date overview. Children, 9(6), 904. https://doi.org/3390/children9060904
- De Luca, C.R., Leventer, R.J. (2010). Developmental trajectories of executive functions across the lifespan. In: Executive functions and the frontal lobes, 57—90. Psychology Press. https://doi.org/4324/9780203837863
- Deviaterikova, A., Kasatkin, V., Malykh, S. (2023). The role of the cerebellum in visual-spatial memory in pediatric posterior fossa tumor survivors. Cerebellum, 23, 197—203. https://doi.org/10.1007/s12311-023-01525-5
- Digital cognitive assessments. Cambridge Cognition. URL: https://cambridgecognition.com/digital-cognitive-assessments/ (Accessed: 23.04.2024)
- Gonçalves, T E., Zimmermann, G.S., Figueiredo, L.C., Souza, M.deC., da Cruz, D.F., Bastos, M.F., da Silva, H.D., Duarte, P.M. (2015). Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up. Journal of clinical periodontology, 42(5), 431—439. https://doi.org/10.1111/jcpe.12396
- Hanzlik, E., Woodrome, S. E., Abdel-Baki, M., Geller, T.J., Elbabaa, S.K. (2015). A systematic review of neuropsychological outcomes following posterior fossa tumor surgery in children. Child's Nervous System, 31, 1869—1875. https://doi.org/1007/s00381-015-2867-3
- Jacobi, H., Faber, J., Timmann, D., Klockgether, T. (2021). Update cerebellum and cognition. Journal of neurology, 268(10), 3921—3925. https://doi.org/10.1007/s00415-021-10486-w
- Marusak, H.A., Iadipaolo, A.S., Harper, F.W., Elrahal, F., Taub, J.W., Goldberg, E., Rabinak, C.A. (2018). Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes. Neuropsychology review, 28, 123—175. https://doi.org/1007/s11065-017-9365-1
- Mironets, S., Shurupova, M., Dreneva, A. (2022). Reading in children who survived cerebellar tumors: Evidence from eye movements. Vision, 6(1), 10. https://doi.org/10.3390/vision6010010
- Ostrom, Q.T., Cioffi, G., Waite, K., Kruchko, C., Barnholtz-Sloan, J.S. (2021). CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro-oncology, 23(12 Suppl. 2), iii1–iii105. https://doi.org/1093/neuonc/noab200
- Pelzer, E. A., Melzer, C., Timmermann, L., von Cramon, D.Y., Tittgemeyer, M. (2017). Basal ganglia and cerebellar interconnectivity within the human thalamus. Brain structure & function, 222(1), 381—392. https://doi.org/10.1007/s00429-016-1223-z
- Ramjan, S., Levitch, C., Sands, S., Kim, S.Y., Barnett, M., Bledsoe, J., Holland, A.A. (2023). Executive and social functioning in pediatric posterior fossa tumor survivors and healthy controls. Neuro-Oncology Practice, 10(2), 152—161. https://doi.org/1093/nop/npac090
- Shurupova, M., Deviaterikova, A., Latanov, A., Kasatkin, V. (2020). Interaction between oculomotor impairments, voluntary attention and working memory disorders in children with cerebellar tumors. In: Velichkovsky, B.M., Balaban, P.M., Ushakov, V.L. (eds). Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics (pp. 547—553). Intercognsci 2020. Advances in Intelligent Systems and Computing, vol. 1358. Springer, Cham. https://doi.org/10.1007/978-3-030-71637-0_63
- Tanedo, J., Gajawelli, N., Guo, S., Baron Nelson, M., Lepore, N. (2022). White matter tract changes in pediatric posterior fossa brain tumor survivors after surgery and chemotherapy. Frontiers in Neuroimaging, 1, art. 845609. https://doi.org/10.3389/fnimg.2022.845609
- Tomlinson, S.P., Davis, N.J., Morgan, H.M., Bracewell, R.M. (2014). Cerebellar contributions to verbal working memory. Cerebellum, 13(3), 354—361. https://doi.org/1007/s12311-013-0542-3
- Zilli, T., Dolcemascolo, V., Passone, E., Maieron, M., De Colle, M.C., Skrap, M., Ius, T., Liguoro, I., Venchiarutti, M., Cogo, P., Tomasino, B. (2021). A multimodal approach to the study of children treated for posterior fossa tumor: A review of the literature and a pilot study. Clinical neurology and neurosurgery, 207, art. 106819. https://doi.org/10.1016/j.clineuro.2021.106819
Information About the Authors
Contribution of the authors
Sofia A. Mironets — ideas; preparation of the primary version of the article; data collection and analysis; application of statistical methods for data analysis; final approval of the article version for publication
Alena A. Deviaterikova — ideas; preparation of the primary version of the article; editing of the article; application of statistical methods for data analysis; final approval of the article version for publication.
Marina A. Shurupova — preparation of the primary version of the article; review and editing of the article; application of statistical methods for data analysis; final approval of the article version for publication.
Sergey B. Malykh — research methodology; review and editing of the article; final approval of the article version for publication.
All authors participated in the discussion of the results and approved the final text of the manuscript.
Conflict of interest
The authors declare no conflict of interest.
Ethics statement
Informed consent for the study was signed by all participants over the age of 15. Consent to conduct the study on participants under 15 years of age was given by their legal representatives. The study conforms to the principles of the Helsinki Declaration, and the Ethical Committee of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology has approved the protocol for the experiment (No. 8e/15-17, dated 27/10/2017).
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