Interrelation of Reduction of Mismatch Negativity and Cognitive Deficit in Paranoid Schizophrenia

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Abstract

This study shows a relationship between the reduction of mismatch negativity (MMN) and the structure and severity of cognitive deficits in patients with paranoid schizophrenia. The study involved 19 patients with paranoid schizophrenia and 43 healthy subjects. The results of BACS and the psychophysiological research method of event related potentials (ERPs) found a relationship between the reduction of MMN and limited verbal working memory, reduced information processing speed and verbal fluency in patients with paranoid schizophrenia. The findings support the hypothesis posed about the importance of early information processing on the formation of cognitive deficits in patients with paranoid schizophrenia patients.

General Information

Keywords: cognitive deficits, mismatch negativity, MMN, paranoid schizophrenia, working memory, attention, event related potentials, BACS

Journal rubric: Clinical Psychology and Psychophysiology

Article type: scientific article

For citation: Petrov M.V., Kolchev A.I., Ershov B.B., Gvozdetckii A.N., Golovanova I.V., Daeva N.A. Interrelation of Reduction of Mismatch Negativity and Cognitive Deficit in Paranoid Schizophrenia. Vestnik of Saint Petersburg University. Psychology, 2017. Vol. 7, no. 1, pp. 91–103. (In Russ., аbstr. in Engl.)

References

Naatanen R., Alho K. Generators of electrical and magnetic mismatch responses in humans. Brain Topography, 1995, vol. 7, pp. 315–320.

Information About the Authors

Maksim V. Petrov, PhD in Psychology, Deputy Chief of the Psychology Service, Saint-Petersburg State Budgetary Institution of Health Care «Kashchenko Psychiatric Hospital №1», St.Petersburg, Russia, ORCID: https://orcid.org/0000-0002-4370-7212, e-mail: max.petrov.phd@gmail.com

Aleksandr I. Kolchev, Doctor of Medicine, Professor, Military Medical Academy named after S. M. Kirov, St.Petersburg, Russia, e-mail: a.kolchev1@gmail.com

Boris B. Ershov, PhD in Psychology, Senior Lecturer, North-West State Medical University, St.Petersburg, Russia, e-mail: magus@nxt.ru

Anton N. Gvozdetckii, PhD in Medicine, Assistant Professor of Chair of Psychiatry and Addiction Medicine, North-Western State Medical University named after I.I. Mechnikov, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0001-8045-1220, e-mail: comisora@yandex.ru

Irina V. Golovanova, PhD in Psychology, Senior Researcher, Scientific Center for Cognitive Research, Sirius University of Science and Technology, Federal territory "Sirius", Russia, ORCID: https://orcid.org/0000-0002-0826-6386, e-mail: golovanova.iv@talantiuspeh.ru

Natalia A. Daeva, psychologist, The City Psychoneurological Dispensary No. 7, St.Petersburg, Russia, e-mail: hon73@yandex.ru

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