Psychological Adjustment To Hematopoietic Stem Cell Transplantation In Adolescents: Individual And Family Factors

The results of the study of individual factors of psychological adaptation to the stressful situation of treatment by hematopoietic stem cells transplantation in adolescents and their mothers are presented. Measures were obtained from 28 adolescents aged 11—18 (M=14,25, 16m/12f) and their mothers aged 31—53 (M=41,1). The results show a significant positive correlation between levels of adjustment of adolescents and their mothers (r=0,643, p=0,001), between levels of adjustment to treatment and emotional distress of adolescents (r=0,544; p=0,007). The original hypothesis of significant associations between the levels of emotional distress, adjustment and individual factors such as appraisal of stressful event was confirmed: the lower level of adolescent’s adjustment was associated with their mothers’ appraisal of HSCT as a Threat (r=0,463, p=0,030) or Loss (r=0,450, p=0,035); high level of adolescent’s distress was associated with his/hers subjective appraisal of HSCT as a Threat (r=0,695, p=0,000) and Loss (r=0,659, p=0,000). Significant associations were also found between psychological adjustment of adolescents and coping behavior (of ad- olescents and parents), which confirms the importance of further research on both individual and family factors of psychological adjustment to HSCT.

1. Belorukova N.O. Semeinye trudnosti i sovladanie s nimi na raznykh etapakh zhiznen- nogo tsikla sem’i [Family difficulties and coping with them at different stages of the life cycle of the family]. In T.L. Kryukova, M.V. Saporovskaya (eds.). Sem’ya: stress, kop- ing, adaptatsiya. Problemy psikhologii sovladayushchego povedeniya v semeinom kontek- ste [Family: stress, coping, adaptation. Problems in the psychology of coping behavior in a family context]. Kostroma: Publ. KGU named after N.A. Nekrasov, 2003, pp. 32—59.
2. Berebin M.A., Vasserman L.I. Faktory riska pogranichnykh nervno-psikhicheskikh i psikhosomaticheskikh rasstroistv u pedagogov obshcheobrazovatel’nykh shkol [Risk factors for borderline neuropsychiatric and psychosomatic disorders among teachers in regular schools]. Obozrenie psikhiatrii i meditsinskoi psikhologii im. V.M. Bekhte- reva [Review of psychiatry and medical psychology named after V.M. Bekhterev], 1994, no. 4, pp. 12—22.
3. Berebin M.A. K voprosu o terminakh, svyazannykh s fenomenologiei psikhicheskoi adaptatsii [To the question of terms connected with the phenomenology of mental adaptation]. Materialy Sibirskogo psikhologicheskogo foruma (16—18 sentyabrya 2004 g.) [Materials of the Siberian Psychological Forum (16th—18th September, 2004)]. Tomsk: Tomskii gosudarstvennyi universitet, 2004, pp. 341—345.
4. Berezin F.B. Psikhicheskaya i psikhofiziologicheskaya adaptatsiya cheloveka [Psy- chological and psychophysiological adaptation]. Leningrad: Nauka, 1988. 270 p.
5. Vasserman L.I., Ababkov V.A., Trifonova E.A. Sovladanie so stressom: teoriya i psikhodiagnostika [Coping with stress: theory and psycho-diagnostics]. Saint Pe- tersburg: Rech’, 2010. 192 p.
6. Vasserman L.I., Bizyuk A.P., Iovlev B.V. Primenenie integrativnogo testa trevozh- nosti (ITT) [The use of integrative anxiety test (IAT)]. Saint Petersburg, 2005. 23 p.
7. Gushchina T.V. Zashchitnoe i sovladayushchee povedenie v disfunktsional’noi sem’e v period krizisa. Avtoref. dis. … kand. psikhol. nauk. [Protective and coping behavior in a dysfunctional family in times of crisis. Ph.D. (Psychology) Thesis]. Kostroma, 2005. 25 p.
8. Zav’yalova E.K. Psikhologicheskii mekhanizmy sotsial’noi adaptatsii cheloveka [Psychological mechanisms of social adaptation of a person]. Vestnik Baltiiskoi ped- agogicheskoi akademii [Bulletin of the Baltic Pedagogical Academy], 2001, issue 40, pp. 55—60.
9. Ivanov P.A., Garanyan N.G. Aprbatsiya oprosnika koping-strategii (COPE) [Ap- probation of a questionnaire of coping strategies (COPE)]. Psikhologicheskaya nauka i obrazovanie [Psychological Science and Education], 2010, no. 1, pp. 82—93.
10. Isaev D.N. Emotsional’nyi stress, psikhosomaticheskie i somatopsikhicheskie rasstroistva u detei [Emotional stress, psychosomatic and somatopsychic disorders in children]. Saint Petersburg: Rech’, 2005. 400 p.
11. Isaeva E.R. Koping-povedenie i psikhologicheskaya zashchite lichnosti v usloviyakh zdorov’ya i bolezni [Coping behavior and psychological defence of the individual in conditions of health and illness]. Saint Petersburg: Publ. SPbGMU, 2009. 136 p.
12. Kiyan I.G. Psikhologicheskie osobennosti detei, proshedshikh kurs khimioterapii OLL (s remissiei ot 2 do 7 let) [Psychological features of children who underwent a course of chemotherapy ALL (with remission from 2 to 7 years)]. Zhurnal prikladnoi psikhologii [Journal of Applied Psychology], 2003, no. 3, pp. 34—44.
13. Klipinina N.V., Enikolopov S.N. Napravleniya issledovanii distressa roditelei detei, prokhodyashchikh lechenie ot zhizneugrozhayushchikh zabolevanii [Areas of study of the distress of parents of children undergoing treatment from life-threatening diseas- es]. Obozrenie psikhiatrii i klinicheskoi psikhologii im. V.M. Bekhtereva [Review of psy- chiatry and medical psychology named after V.M. Bekhterev], 2016, no. 1, pp. 29—37.
14. Kryukova T.L. Chelovek kak sub»ekt sovladayushchego povedeniya [Man as the sub- ject of coping behavior]. Psikhologicheskii zhurnal, 2008. Vol. 2, no. 2, pp. 88—95.
15. Kryukova T.L. Metody sovladayushchego povedeniya: tri koping-shkaly. 2-e izd., ispravlennoe, dopolnennoe [Methods of coping behavior: three coping-scales: 2nd edition, revised, supplemented]. Kostroma: KGU named after N.A. Nekrasov — Avantitul, 2010. 64 p.
16. Kudryavitskii A.R., Khain A.E., Klipinina N.V. Obosnovanie kompleksnogo podk- hoda v rabote psikhologicheskoi sluzhby, soprovozhdayushchei lechebnyi protsess, v detskoi onkologii/gematologii [Substantiation of the complex approach in the work of the psychological service accompanying the medical process in children’s oncology / hematology]. Voprosy gematologii/onkologii i immunopatologii v pediatrii [Problems of hematology / oncology and immunopathology in pediatrics], 2006. Vol. 5, no. 3, pp. 41—48.
17. Kuftyak E.V. Issledovanie ustoichivosti sem’i pri vozdeistvii trudnostei [Elektronnyi resurs] [The study of family resilience under difficult situations]. Psikhologicheskie issledovaniya [Psychological Studies], 2010. Vol. 6, no. 14. Available at: http://psys- tudy.ru (Accessed: 03.04.2016) (In Russ., abstr in Engl.).
18. Kuftyak E.V. Faktory stanovleniya sovladayushchego povedeniya v detskom i po- drostkovom vozraste [Factors of development of coping behavior in children and adolescents]. Psikhologicheskie issledovaniya [Psychological Studies], 2012. Vol. 2, no. 22. Available at: http://psystudy.ru (Accessed: 27.07.2016). (In Russ., abstr in Engl.).
19. Mel’nikova N.N. Diagnostika sotsial’no-psikhologicheskoi adaptatsii lichnosti: Uchebnoe posobie [Diagnosis of socio-psychological adaptation of the personality: Manual]. Chelyabinsk: Publ. YuUrGU, 2004. 57p.
20. Nikol’skaya I.M., Granovskaya R.M. Psikhologicheskaya zashchita u detei [Psycho- logical defence in children]. Saint Petersburg: Rech’, 2006. 342 p.
21. Padun M.A., Kotel’nikova A.V. Metodika issledovaniya bazisnykh ubezhdenii li- chnosti [Methodology for the study of the basic beliefs of the individual]. Moscow: IP RAN, 2007. 23 p.
22. Rean A.A., Kudashev A.R., Baranov A.A. Psikhologiya adaptatsii lichnosti [Psychol- ogy of personality adaptation]. Saint Peterburg: Praim-EVROZNAK, 2008. 479 p.
23. Sirota H.A., Yaltonskii V.M. Preodolenie emotsional’nogo stressa podrostkami. Model’ issledovaniya [Overcoming of emotional stress by adolescents. Research model]. Obozrenie psikhiatrii i meditsinskoi psikhologii im. V.M. Bekhtereva [Re- view of psychiatry and medical psychology named after V.M. Bekhterev], 1993, no. 1, pp. 53—60.
24. Sokolova E.T., Nikolaeva V.V. Osobennosti lichnosti pri pogranichnykh rasstroist- vakh i somaticheskikh zabolevaniyakh [Features of personality in borderline disor- ders and somatic diseases]. Moscow: SvR-Argus, 1995. 360 p.
25. Sukhanov A.A. Vidy, formy adaptatsii v psikhologicheskoi nauke [Types and forms of adjustment in psychology]. In N.M. Saraeva and others (eds.). Psikhologiches- kachya adaptatsiya i psikhologicheskoe zdorov’e cheloveka v oslozhnennykh usloviyakh zhiznennoi sredy [Psychological adaptation and psychological health of a person in the complicated conditions of the living environment]. Moscow: Akademiya estestvoznani- ya, 2011. 321 p.
26. Tarabrina N.V., Vorona O.A., Kurchakova M.S., Padun M.A., Shatalova N.E. Onkopsikhologiya: posttravmaticheskii stress u bol’nykh rakom molochnoi zhelezy. Moscow: IP RAN, 2010. 175 p.
27. Tarabrina N.V. Praktikum po psikhologii posttravmaticheskogo stressa. [Workshop on the psychology of post-traumatic stress]. Saint Petersburg: Piter, 2001. 272 p.
28. Tolstykh N.N. Prikhozhan A.M. Psikhologiya podrostkovogo vozrasta: uchebnik i praktikum dlya akademicheskogo bakalavriata [Psychology of adolescence: a text- book and a workshop for academic undergraduates]. Moscow: Yurait, 2016. 406 p.
29. Tkhostov A.Sh. Psikhologiya telesnosti [Psychology of Corporeality], Moscow: Smysl, 2002. 287 p.
30. Uryadnitskaya N.A. Psikhologicheskaya samoregulyatsiya u detei s onkologicheskoi patologiei. Avtoref. dis. … kand. psikhol. nauk. [Psychological self-regulation in chil- dren with oncological pathology. Ph.D. (Psychology) Thesis]. Moscow, 1998. 20 p.
31. Khazova S.A. Koping-resursy sub»ekta: osnovnye napravleniya i perspektivy issle- dovaniya [The subject’s coping resources: the main directions and prospects of the research]. Vestnik KGU im. N.A. Nekrasova [Bulletin of KSU named after N.A. Nekra- sov], 2013, no. 5, pp. 188—191.
32. Khain A.E., Klipinina N.V., Nikol’skaya N.S., Orlov A.B., Evdokimova M.A., Ste- fanenko E.A., Kudryavitskii A.R. Opyt sozdaniya i raboty psikhologicheskoi slu- zhby v detskoi gematologii/onkologii [Experience in the creation and operation of psychological services in pediatric hematology / oncology]. Konsul’tativnaya psik- hologiya i psikhoterapiya [Counseling Psychology and Psychotherapy], 2014, no. 1, pp. 106—126. (In Russ., abstr. in Engl.).
33. Khain A.E., Klipinina N.V., Kudryavitskii A.R., Nikol’skaya N.S., Stefanenko E.A., Evdokimova M.A. Psikhosotsial’naya adaptatsiya k lecheniyu u detei s ty- azhelymi somaticheskimi zabolevaniyami [Psychosocial adaptation to treatment in children with severe physical illnesses]. Voprosy gematologii/onkologii i immunologii v pediatrii [Problems of hematology / oncology and immunopathology in pediatrics], 2014, no. 4, pp. 56—63.
34. Khain A.E. Psikhologicheskie aspekty transplantatsii gemopoeticheskikh stvolovykh kletok (TGSK) u detei. [Psychological aspects of pediatric hematopoietic stem cell transplantation]. Konsul’tativnaya psikhologiya i psikhoterapiya [Counseling Psychol- ogy and Psychotherapy], 2015. Vol. 23, no. 1, pp. 116—125. (In Russ., abstr. in Engl.).
35. Khain A.E., Kholmogorova A.B., Ryabova T.V. Uroven’ i dinamika distressa v se- meinoi sisteme u patsientov podrostkovogo vozrasta, prokhodyashchikh lechenie v otdelenii transplantatsii gemopoeticheskikh stvolovykh kletok (TGSK) [The level and dynamics of distress in the family system in adolescents undergoing treatment in the department of hematopoietic stem cell transplantation (HSCT)]. In
36. A.L. Zhuravlev, E.A. Sergienko, N.V. Tarabrina, N.E. Kharlamenkova (eds.). Psik- hologiya povsednevnogo i travmaticheskogo stressa: ugrozy, posledstviya i sovladanie [Psychology of everyday and traumatic stress: threats, consequences and coping]. Mos- cow: IP RAN, 2016. 496 p.
37. Kholmogorova A.B. Biopsikhosotsial’naya model’ kak metodologicheskaya osnova izucheniya psikhicheskikh rasstroistv [Biopsychosocial model as a methodological basis for studying mental disorders]. Klinicheskaya i sotsial’naya psikhiatriya [Clini- cal and social psychiatry], 2002, no. 3, pp. 97—105.
38. Kholmogorova A.B., Volikova S.V., Kalina O.G. Metodicheskie rekomendatsii: primenenie oprosnika detskoi depressii M. Kovak (CDI) [Methodical recommen- dations: use of the questionnaire of childhood depression by M. Kovak (CDI)]. Moscow: FGBU «MNIIP», 2013. 24 p.
39. Ferguson E., Matthews G., Cox T. The appraisal of life events (ALE) scale: reli- ability, and validity. British Journal of Health Psychology, 1999, no. 4, pp. 97—116. doi:10.1348/135910799168506
40. Krohne H.W., Egloff B., Varner L.J., Burns L.R., Weidner G., Ellis H.C. The as- sessment of dispositional vigilance and cognitive avoidance: Factorial structure, psy- chometric properties, and validity of the Mainz Coping Inventory. Cognitive Therapy and Research, 2000. Vol. 24, pp. 297—311. doi:10.1023/A:1005511320194
41. Lazarus R.S. From psychological stress to the emotions: A history of changing out- looks. Annual Review of Psychology, 1993. Vol. 44, pp. 1—21. doi:10.1146/annurev. ps.44.020193.000245
42. Marcus J. Psychosocial issues in pediatric oncology. The Ochesner Journal, 2012. Vol. 12, pp. 211—215.
43. Walsh F. (ed.). Normal family processes: Growing diversity and complexity (4th ed.). New York: Guilford Press, 2012. 482 p.
44. Patel S.K., Mullins W., Turk A., Dekel N., Kinjo C., Sato J.K. Distress screening, rater agreement, and services in pediatric oncology. Psycho-Oncology, 2011. Vol. 20, pp. 1324—1333. doi:10.1002/pon.1859
45. Patenaude A.F. Psychological impact of bone marrow transplantation: current per- spectives. The Yale Journal of Biology and Medicine, 1999. Vol. 63, pp. 515—519.
46. Patenaude A.F., Kupst M.J. Psychosocial functioning in pediatric cancer, Journal of pediatric psychology, 2005. Vol. 30 (1), pp. 9—27. doi:10.1093/jpepsy/jsi012
47. Phipps S., Dunavant M., Lensing S., Rai S.N. Brief report: Patterns of Distress in Parents of Children Undergoing Stem Cell Transplantation. Pediatric Blood Cancer, 2004, no. 43, pp. 267—274. doi:10.1002/pbc.20101
48. Phipps S., Dunavant M., Lensing S., Rai S.N. Psychosocial Predictors of Distress in Parents of Children Undergoing Stem Cell or Bone Marrow Transplantation. Journal of Pediatric Psychology, 2005, Vol. 30 (2), pp. 139—153. doi:10.1093/jpepsy/jsi002
49. Holland J.C., Breibart W.C., Butow P.N., Jacobsen P.B., Loscalzo M.J., Mc- Corkle R. (eds.). Psycho-Oncology. Oxford: Oxford University Press, 2015. 864 p.
50. Vrijmoet-Wiersma C.M.J., Egeler R.M., Koopman H.M., Norberg A.L., Grooten- huis M.A. Parental stress before, during and after pediatric stem cell transplantation: a review article. Support Care in Cancer, 2009. Vol. 17, pp. 1435—1443. doi:10.1007/ s00520-009-0685-4