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Clinical Psychology and Special Education
2020. Vol. 9, no. 1, 78–103
doi:10.17759/cpse.2020090105
ISSN: 2304-0394 (online)

Psychic State and Cognitive Function in HIV-infected Patients and Functional State of the Brain Structures (According to Positron Emission Tomography and Magnetic Resonance Spectroscopy)

368

E.A. Gromova, G.V. Kataeva, I.G. Khomenko, I.A. Kotomin, A.A. Bogdan, A.V. Kosych, V.V. Rassokhin, N.A. Belyakov, T.N. Trofimova

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Abstract

The article presents the results of the study of cognitive functions and the psychic state of HIV-infected patients. 38 patients aged 25-45 years were examined. In HIV-infected patients, dysfunctions of the central nervous system observed, which could be detected in the early stages after infection. Indicators of cognitive functions and psychic state correlated with the metabolism of the cerebral cortex, mainly with the metabolism of structures associated with executive functions. Obviously, patients of presented category have a decline in executive functions. Therefore, it is important to include psychocorrective treatment aimed at training of emotional-volitional functions, in the rehabilitation program which should also contribute to the improvement of cognitive functions and better social adaptation. The revealed changes in glucose metabolism and the content of N-acetyl aspartate were nonspecific and could be caused by a combination of the direct effect of the virus on the brain tissue, psychogenic and premorbid factors. Most likely, the existing premorbid features enhanced by the toxic effects of HIV and severe psycho-emotional stress associated with obtaining information about infection.

General Information

Keywords: HIV infection, positron emission tomography, magnetic resonance spectroscopy, cognitive impairment

Journal rubric: Empirical Research

Article type: scientific article

DOI: https://doi.org/10.17759/cpse.2020090105

For citation: Gromova E.A., Kataeva G.V., Khomenko I.G., Kotomin I.A., Bogdan A.A., Kosych A.V., Rassokhin V.V., Belyakov N.A., Trofimova T.N. Psychic State and Cognitive Function in HIV-infected Patients and Functional State of the Brain Structures (According to Positron Emission Tomography and Magnetic Resonance Spectroscopy) [Elektronnyi resurs]. Klinicheskaia i spetsial'naia psikhologiia = Clinical Psychology and Special Education, 2020. Vol. 9, no. 1, pp. 78–103. DOI: 10.17759/cpse.2020090105. (In Russ., аbstr. in Engl.)

References

  1. Akulova M.V.  Sotsial'no-psikhologicheskie problemy integratsii v sotsium semei, zatronutykh epidemiei VICh-infektsii [The socio-psychological challenges of the integration of families affected by HIV infection into socialty]. Konsul'tativnaya psikhologiya i psikhoterapiya [Counseling Psychology and Psychotherapy], 2015, vol. 23, no. 4, pp. 69–82. doi:10.17759/cpp.2015230405. (In Russ., аbstr. in Engl.)
  2. Gaisina A.V., Magonov E.P., Gromova E.A., et al. Patologicheskie mekhanizmy VICh-assotsiirovannykh neirokognitivnykh rasstroistv [Pathological mechanisms of HIV-associated neurocognitive frustration] Luchevaya diagnostika i terapiya [Diagnostic Radiology and Radiotherapy], 2016, vol. 7, no 2, pp. 6–21. (in Russ., abstr. in Engl.)
  3. Gromova E.A., Bogdan A.A., Kataeva G.V., et al. Osobennosti funktsional'nogo sostoyaniya struktur golovnogo mozga u VICh-infitsirovannykh patsientov. [Peculiarities of the brain functional state in HIV patients]. Luchevaya diagnostika i terapiya [Diagnostic Radiology and Radiotherapy], 2016, vol. 7, no. 1, pp. 41–48. (in Russ., abstr. in Engl.).
  4. Gromova E.A. Metabolicheskie izmeneniya v golovnom mozge u VICh-infitsirovannykh patsientov po dannym pozitronno-emissionnoi tomografii s 2-18F-ftordezoksi D-glyukozoi i protonnoi magnitno-rezonansnoi spektroskopii. Diss. kand. med. nauk [Metabolic changes in the brain of HIV positive patients according to the PET and MRS data. PhD (medicine) Thesis].  Saint-Petersburg, 2018. 120 p.
  5. Kataeva G.V., Korotkov A.D., Mel'nichuk K.V. Patterny otnositel'nykh otsenok regionarnogo mozgovogo krovotoka i skorosti metabolizma glyukozy v zdorovom mozge cheloveka [Patterns of relative values of regional cerebral blood flow and glucose metabolism rate in the healthy human brain]. Meditsinskaya vizualizatsiya [Medical Neuroimaging], 2007, no. 2, pp. 84–92. (in Russ.)
  6. Makhamatova, A.F. The Problem of Relationships Between Doctor and HIV-Infected Patient [Elektronnyi resurs]. Klinicheskaia i spetsial'naia psikhologiia [Clinical Psychology and Special Education], 2016, vol. 5, no. 2, pp. 23–32. doi: 10.17759/psycljn. 2016050202 (In Russ., abstr. in Engl.)
  7. Medvedev S.V., Skvortsova T.Yu., Krasikova R.N. PET v Rossii: pozitronno-emissionnaya tomografiya v klinike i fiziologii [PET in Russia: positron emission tomography in clinics and physiology]. Saint-Petersburg: AST, 2008. 318 p. (in Russ.)
  8. Neznanov N.G., Khalezova N.B. Osobennosti sovladayushchego povedeniya u VICh-infitsirovannykh bol'nykh. [Peculiarities of coping behavior in HIV infected patients]. Ekologiya cheloveka [Human Ecology], 2010, vol. 4, pp. 10–15. (in Russ.)
  9. Neznanov N.G., Khalezova N.B., Khobeish M.A., et al. Kliniko-neirofiziologicheskie osobennosti psikhicheskikh rasstroistv u bol'nykh VICh-infektsiei. Obozrenie psikhiatrii i meditsinskoi psikhologii [V.M. Bekhterev Review of Psychiatry and Medical Psychology], 2018, no. 4., pp. 52–63. doi: 10.31363/2313-7053-2018-4-53-63 (in Russ., abstr. in Engl.)
  10. Tarabrina N.V. Praktikum po psikhologii posttravmaticheskogo stressa [Handbook on psychology of posttraumatic stress]. Saint-Petersburg: Piter, 2001. 272 p. (in Russ.)
  11. Trofimova T.N., Kataeva G.V., Gromova E.A., et al. VICh-assotsiirovannye neirokognitivnye narusheniya: diagnostika, vyyavlenie prichin i effektivnost' terapii [HIV-associated neurocognitive disorders: diagnosis, detection of causes and therapy efficiency]. VICh-infektsiya i immunosupressii [HIV Infection and Immunosuppressive Disorders], 2018, vol. 10, no. 4, pp. 7–24. doi: 10.22328/2077-9828-2018-10-4-7-24 (in Russ., abstr. in Engl.).
  12. Anderson B.A., Kronemer S.I., Rilee J.J., et al. Reward, attention, and HIV-related risk in HIV+ individuals. Neurobiology of Disease, 2016, vol. 92 (Part B), pp. 157–165. doi: 10.1016/j.nbd.2015.10.018
  13. Baddeley A., Emslie H., Kolodny J., et al. Random generation and the executive control of working memory. Quarterly Journal of Experimental Psychology, 1998, vol. 51, no. 4, pp. 819–852. doi: 10.1080/713755788
  14. Barker P.B., Bizzi A., De Stefano N., et al. Clinical MR Spectroscopy: Techniques and Applications. New York: Cambridge University Press, 2009. 256 p.  doi: 10.1017/ cbo9780511770647
  15. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society, 1995, vol. 57, pp. 289–300.
  16. Cohen R.A., Siegel S., Gullett J.M., et al. Neural response to working memory demand predicts neurocognitive deficits in HIV. Journal of Neurovirology, 2018, vol. 24,
    no. 3, pp. 291–304. doi: 10.1007/s13365-017-0607-z
  17. Derogatis L.R., Cleary P.A. Factorial invariance across gender for the primary symptom dimension of the SCL-90. British Journal of Social and Clinical Psychology, 1977, vol. 16, no. 4, pp. 347–356. doi: 10.1111/j.2044-8260.1977.tb00241.x
  18. Du Plessis S., Vink M., Joska J., et al. HIV infection and the fronto-striatal system:
    a systematic review and meta-analysis of fMRI studies. AIDS, 2014, vol. 28, pp. 803–811. https:.doi.org/10.1097/qad.0000000000000151
  19. Ellis R.J., Calero P., Stockin M.D. HIV infection and the central nervous system:
    a primer. Neuropsychology Review, 2009, vol. 19, no. 2, pp. 144–151. doi: 10.1007/s11065-009-9094-1
  20. Evans A.C., Kamber M., Collins D.L., et al. An MRI-based probabilistic atlas of neuroanatomy. In S.D. Shorvon, et al (eds.), Magnetic Resonance Scanning and Epilepsy. New York, NY: Springer, 1994, pp. 263–274. doi: 10.1007/978-1-4615-2546-2_48
  21. Fornito A., Yücel M., Dean B., et al. Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology. Schizophrenia Bulletin, 2009, vol. 35, no. 5, pp. 973–993.
    doi: 10.1093/schbul/sbn025
  22. Handbook of Executive function. S. Goldstein, J. Naglieri (eds.). New York: Springer, 2014. 555 p. doi: 10.1007/978-1-4614-8106-5
  23. Hazari N., Narayanaswamy J.C, Venkatasubramanian G. Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings. Indian Journal of Psychiatry, 2019, vol. 61, no. 1, pp. 9–29.
    doi: 10.4103/psychiatry.IndianJPsychiatry_525_18
  24. Heaton R.K., Franklin D.R., Ellis R.J., et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. Journal of Neurovirology, 2011, vol. 17, no. 1, pp. 3–16.
    doi: 10.1007/s13365-010-0006-1
  25. Hinkin C.H., Castellon S.A., Durvasula R.S., et al. Medication adherence among HIV+ adults: effects of cognitive dysfunction and regimen complexity. Neurology, 2002, vol. 59, no. 12, pp. 1944–1950. doi: 10.1212/01.wnl.0000038347.48137.67
  26. Iudicello J.E., Woods S.P., Weber E., et al. HIV Neurobehavioral Research Center (HNRC) Group. Cognitive mechanisms of switching in HIV-associated category fluency deficits. Journal of Clinical and Experimentl Neuropsycholology, 2008, vol. 30, no. 7,
    pp. 797–804. doi: 10.1080/13803390701779578
  27. Jiang X., Barasky R., Olsen H., et al. Behavioral and neuroimaging evidence for impaired executive function in "cognitively normal" older HIV-infected adults. AIDS Care, 2015, vol. 17, pp. 1–5. doi: 10.1080/09540121.2015.1112347 
  28. Kübler A., Dixon V., Garavan H. Automaticity and reestablishment of executive control-an fMRI study. Journal of Cognitive Neuroscience, 2006, vol. 18, no. 8,
    pp. 1331–1342. doi: 10.1162/jocn.2006.18.8.1331
  29. McDonald J.H. Handbook of Biological Statistics (3rd ed.), Baltimore, Maryland: Sparky House Publishing, 2014, pp. 254–260. URL: http://www.biostathandbook.com/ multiplecomparisons.html (Accessed 20.03.2020)
  30. McIntosh R.С., Rosselli M., Uddina L.Q., et al. Neuropathological sequelae of Human Immunodeficiency Virus and apathy: A review of neuropsychological and neuroimaging studies. Neuroscience and Biobehavioral Reviews, 2015, vol. 55, pp. 147–164.
    doi: 10.1016/j.neubiorev.2015.04.008
  31. Owen A.M. Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitry. Neuroscientist, 2004, vol. 6, pp. 525–537. doi: 10.1177/1073858404266776
  32. Rosenberg D.R., Mirza Y., Russell A., et al.  Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls. Journal of American Academy of Child and Adolescent Psychiatry, 2004, vol. 43,
    no. 9, pp. 1146–1153. doi: 10.1097/01.chi.0000132812.44664.2d
  33. Sacktor N., Lyles R.H., Skolasky R., et al. Multicenter AIDS Cohort Study. HIV-associated neurologic disease incidence changes. Neurology, 2001, vol. 56, no. 2,
    pp. 257–260. doi: 10.1212/01.wnl.0000397842.06268.c0
  34. Statistical Parametric Mapping. URL: www.fil.ion.ucl.ac.uk/spm/ (Accessed 12.08.2019).
  35. Su H., Zuo C., Zhang H., et al. Regional cerebral metabolism alterations affect resting-state functional connectivity in major depressive disorder. Quantitative Imaging in Medicine and Surgery, 2018, vol. 8, no. 9, pp. 910–924. doi: 10.21037/qims.2018.10.05
  36. WFU PickAtlas. URL: http:.www.nitrc.org/projects/wfu_pickatlas/ (Accessed 12.08.2019).
  37. Woods S.P., Moore D.J., Weber E., et al. Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychology Review, 2009, vol. 19, no. 2, pp. 152–168. doi: 10.1007/s11065-009-9102-5

Information About the Authors

Elena A. Gromova, PhD in Medicine, Head of the Department, Radiology Department, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0001-7723-8242, e-mail: gromova@ihb.spb.ru

Galina V. Kataeva, PhD in Biology, Scientific Director, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0003-0463-9832, e-mail: galina@ihb.spb.ru

Iuliia G. Khomenko, PhD in Psychology, Researcher, Neuroimaging Laboratory, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0001-7593-499X, e-mail: khomenko@ihb.spb.ru

Ivan A. Kotomin, Engineer, Radiology Department, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0002-8966-4107, e-mail: kotomin@ihb.spb.ru

Andrey A. Bogdan, Junior Researcher of the Laboratory of Stereotactic Methods, N.P. Bechtereva Institute of Human Brain, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0002-2836-1516, e-mail: andrey@ihb.spb.ru

Aleksandra V. Kosych, PhD in Biology, Psychologist, Northwestern District AIDS Prevention and Control Center, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0003-2685-279X, e-mail: allysrb@yandex.ru

Vadim V. Rassokhin, Doctor of Medicine, Professor, Department of Socially Significant Infections, Pavlov First Saint-Petersburg State Medical University, Leading Researcher, Northwestern District AIDS Prevention and Control Center; Saint-Petersburg Pasteur Institute, Leading Researcher, Department of Environmental Physiology, Institute of Experimental Medicine, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0002-1159-0101, e-mail: ras-doc@mail.ru

Nikolay A. Belyakov, Doctor of Medicine, Academician of the Russian Academy of Science, Head of the Department, Department of Socially Significant Infections, Pavlov First Saint-Petersburg State Medical University, Head of the Center, Northwestern District AIDS Prevention and Control Center, Saint-Petersburg Pasteur Institute, Chief Researcher, Department of Environmental Physiology, Institute of Experimental Medicine, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0002-2006-2255, e-mail: beliakov.akad.spb@yandex.ru

Tatiana N. Trofimova, Doctor of Medicine, Professor, Department of Roentgenology and Radioloigy, Pavlov First Saint-Petersburg State Medical University, Chief Researcher, Neuroimaging Laboratory, N.P. Bechtereva Institute of Human Brain, Leading Researcher, Department of Environmental Physiology, Institute of Experimental Medicine, St.Petersburg, Russia, ORCID: https://orcid.org/0000-0003-4871-2341, e-mail: beliakov.akad.spb@yandex.ru

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