Psychophysiological and molecular genetic correlates of fatigue

The article is devoted to a theoretical overview in the field of fatigue, and in particular to recent data on psychophysiological and molecular-genetic correlates of fatigue. Nowadays there exist many methods used to assess fatigue and other functional states: subjective, behavioral and physiological methods. Earlier the studies in the area of fatigue were mainly focused on looking for an objective indicator. The current research focuses on an integral approach. Over recent years the significant progress in molecular biology has been achieved, which provided a significant impact on quality and scope of investigations. Now we can find numerous researches which reflect the link between the presence of certain polymorphisms and expression of behavioral patterns or physiological reactions. Thus, in the present study we make an attempt to reflect the existing psycho-physiological and molecular-genetic correlates of fatigue.

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