Моделирование заболеваний мозга человека в экспериментах на грызунах (краткий обзор) ¹⁴²¹

В обзоре дается краткая сводка успехов и трудностей в создании и использовании биологических моделей заболеваний мозга человека, которая относится к важным проблемам прикладной нейробиологии. В обзоре упоминаются и попытки теоретического осмысления относительной роли генотипа, влияний среды и их динамического взаимодействия (концепция LEARN). Рассматриваются примеры разработанных генетических моделей болезней человека (болезнь Альцгеймера, синдром Дауна, аутизм и др.). Уделено внимание сложной проблеме «нормы» и «патологии» при создании моделей тревожных расстройств человека, а также важности учета и глубокого понимания видоспецифических особенностей поведения животных видов, используемых в качестве биологических моделей такого рода.

Ключевые слова: нейрогенетика, генетика поведения, генетические модели, заболевания мозга человека, модели тревожных расстройств, взаимодействие генотип-среда

Рубрика: Нейронауки

DOI: https://doi.org/10.17759/jmfp.2016050402

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