Интеграция помощи людям с РАС: коморбидные состояния в психиатрии и комплексная терапия

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Аннотация

Сопутствующие психические заболевания осложняют процесс терапии при расстройствах аутистического спектра. В данной статье обсуждаются такие коморбидные состояния, сопутствующие РАС, как синдром дефицита внимания и гиперактивности, тревожность, депрессия, деструктивное расстройство дисрегуляции настроения, психотические и биполярные расстройства. Так как данные заболевания, как правило, затрагивают множество эндофенотипов, от генетического до поведенческого, то и терапия должна быть многоцелевой с максимально сниженными при этом побочными эффектами. Вмешательства с доказанной эффективностью при РАС и коморбидных состояниях могут варьировать от психосоциальной коррекции до лечения психотропными препаратами с различной степенью эффективности в зависимости от сочетания коморбидных состояний и комбинаций терапевтических стратегий. В данном обзоре поставлена цель краткого представления коморбидных состояний при РАС, а также обсуждение возможных вариантов терапии, основанной прежде всего на доказательных исследованиях. Подбор терапии зависит от симптоматики в каждом конкретном случае, но данные свидетельствуют о большей эффективности интегративно-целевой терапии по сравнению с терапией отдельных коморбидных состояний.

Общая информация

Ключевые слова: аутизм, коморбидные состояния, эндофенотипы, интегративная медицина, психосоциальная коррекция, психофармакологическая терапия, медикаментозная терапия

Тип материала: научная статья

DOI: https://doi.org/10.17759/autdd.2021190105

Для цитаты: Паренте Ч.И., Ципан Р.М., Хендрен Р.Л. Интеграция помощи людям с РАС: коморбидные состояния в психиатрии и комплексная терапия // Аутизм и нарушения развития. 2021. Том 19. № 1. С. 44–52. DOI: 10.17759/autdd.2021190105

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Информация об авторах

Паренте Чина И., координатор клинических исследований Департамента психиатрии, Калифорнийский университет, Сан-Франциско, США, ORCID: https://orcid.org/0000-0001-6812-9263, e-mail: China.Parenteau@ucsf.edu

Ципан Рейчел М., научный сотрудник Департамента психиатрии, Калифорнийский университет в Беркли, Сан-Франциско, США, ORCID: https://orcid.org/0000-0002-2585-9415, e-mail: rachel.tsipan@berkeley.edu

Хендрен Роберт Л., DO, профессор психиатрии, директор программы исследований нейроонтогенетических и трансляционных результатов (PRONTO), Калифорнийский университет в Сан-Франциско, Сан-Франциско, США, ORCID: https://orcid.org/0000-0001-8470-4862, e-mail: Robert.Hendren@ucsf.edu

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