Modern Approaches to Diagnosis and Treatment of Cognitive Disorders in Children and Adults

1016

Abstract

The article regards etiology and pathogenesis of some inherited mental diseases which are entailed frank cognitive disorders. It describes psychoneurological disorders during diseases such as neurofibromatosis, tuberous sclerosis, X-linked mentally retardation syndrome, Rett's syndrome. Their separation from the group of undifferential forms becomes available with improvement of genetic methods of analysis. Defining genes in which mutations entailed disorders in mental development gives an opportunity to create models of these disorders on animals and study their pathogenesis mechanisms. The article discusses approaches to therapy of cognitive disorders based on understanding of signal pathway functioning. It also presents first results of pathogeneticaly valid therapy.

General Information

Keywords: inherited mental diseases, cognitive disorders, pathogenesis, therapy.

Journal rubric: Clinical and Special Psychology

Article type: scientific article

For citation: Gorbachevskaya N.L. Modern Approaches to Diagnosis and Treatment of Cognitive Disorders in Children and Adults [Elektronnyi resurs]. Psikhologicheskaya nauka i obrazovanie psyedu.ru [Psychological Science and Education psyedu.ru], 2010. Vol. 2, no. 5 (In Russ., аbstr. in Engl.)

References

  1. Belichenko N. P., Belichenko P.V., Li Vong Hua, Moble W. C., Frank U. Comparative Study Of Brain Morphology. In Mecp2 Mutant Mouse Models of Rett Syndrome // The Journal оf Comparative Neurology. 2008. 508.
  2. Ehninger D., de Vries P. J., Silva A. J. From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis // Journal of Intellectual Disability Research. October 2009. Vol. 53.
  3. Sahin A. M. et al. A mouse model of tuberous sclerosis: neuronal loss of TSC icauses dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival // Journal of  Neuroscience. 2007.
  4. Voinova-Ulas V. Yu., Iourov I. Yu., Gorbachevskaya N. L., Boudilov A.V., Demidova I. A., Giunti L., Sorokin A. B., Prassolov V. S., Villard L. Towards genotype-phenotype correlationsin Rett syndrome: the study of MECP2 mutations and X chromosome inactivation // Gene. Brain. Behavior. Edited by S. B. Malych, A. M. Torgersen. Oslo-Moscow, 2007.
  5. De Vries P. J., Oliver Ch. Intellectual disabilities and genetic disorders can lead the way in translational research // Journal of Intellectual Disability Research. October 2009. Vol. 53.

Information About the Authors

Natalia L. Gorbachevskaya, Doctor of Biology, Professor, Moscow State University of Psychology and Education, Leading Researcher, Laboratory of Neurophysiology, Mental Health Research Centre, Moscow, Russia, ORCID: https://orcid.org/0000-0002-8558-9007, e-mail: gorbachevskayanl@mgppu.ru

Metrics

Views

Total: 3981
Previous month: 17
Current month: 10

Downloads

Total: 1016
Previous month: 3
Current month: 2