Endophenotypes in psychiatric genetics: Experience of ten years long study (Literature overview)



Endophenotypes, as innate characteristics of human organism and psyche, disclosing links with behavioral (psychological) signs in norm and in mental impairments, are regarded as an intermediate link between the action of the gene and its display at the behavioral level. The article presents the role of endophenotypes in study of genetic foundation of psychic diseases. It describes the specific signs of various levels regarded as potential endophenotypes for a number of diseases, primarily schizophrenia. The review provides examples of genes connected with endophenotypes of schizophrenia and some other diseases. It also provides estimation of interpreting potentials of the given notion.

General Information

Keywords: genome; genetic polymorphism; endophenotype; candidate gene, psychiatric genetics; schizophrenia, intellect

Journal rubric: General Psychology

Article type: review article

For citation: Mariutina T.M. Endophenotypes in psychiatric genetics: Experience of ten years long study (Literature overview) [Elektronnyi resurs]. Sovremennaia zarubezhnaia psikhologiia = Journal of Modern Foreign Psychology, 2013. Vol. 2, no. 4, pp. 45–58. (In Russ., аbstr. in Engl.)


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Information About the Authors

Tatyana M. Mariutina, Doctor of Psychology, professor, head Department of Differential Psychology and Psychophysiology, Institute of Psychology named after. L.S. Vygotsky, Russian State University for the Humanities, leading researcher at PI RAO, expert at the Higher Attestation Commission, member of the editorial board of the scientific journal "Psychological Science and Education", member of the editorial board of the scientific journal "Experimental Psychology", Moscow, Russia, e-mail: T.M.Mariutina@rambler.ru



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