Роль наследственности и среды в этиологии нарушений пищевого поведения. I. Обзор семейных исследований ¹⁷¹²

В статье дается обзор зарубежных семейных исследований, оценивающих встречаемость нарушений пищевого поведения (нервной анорексии, нервной булимии и компульсивного переедания) и коморбидных расстройств у родственников первой степени родства. Отечественные исследования такого рода отсутствуют. Результаты анализа указывают на семейный характер нарушений пищевого поведения и более широкий спектр патологических фенотипов у родственников, включая и другие психические расстройства. Средовые семейные факторы риска, видимо, являются неспецифическими и сопутствуют не только нарушениям пищевого поведения, но и другим расстройствам. Вероятно, имеется наследственная предрасположенность, которая переходит в патологический фенотип при определенном стечении обстоятельств.

Ключевые слова: нарушения пищевого поведения, нервная анорексия, нервная булимия, булимия, семейные исследования, наследственность, среда, обзор

Рубрика: Теоретические исследования

Тип: обзорная статья

1. Bould H., Sovio U., Koupil I., Dalman C., Micali N., Lewis G., Magnusson C.. Do eating disorders in parents predict eating disorders in children? Evidence from a Swedish cohort // Acta Psychiatrica Scandinavica. 2015. P. 1–9.
2. Campbell I.C., Mill J., Uher R., Schmidt U. Eating disorders, gene–environment interactions and epigenetics // Neuroscience and Biobehavioral Reviews. 2011. V. 35. P. 784–793.
3. Carney C.P., Yates W.R., Cizadlo B. A controlled family study of personality in normal-weight bulimia nervosa // International Journal of Eating Disorders. 1990. V. 9, Is. 6, P. 659–665.
4. Frieling H., Römer K.D., Scholz S., Mittelbach F., Wilhelm J., Zwaan M. De, Jacoby G.E., Kornhuber J., Hillemacher T., Bleich S. Epigenetic dysregulation of dopaminergic genes in eating disorders // International Journal of Eating Disorders. 2010. V. 43, Is. 7, P. 577–583.
5. Graber J.A., Brooks-Gunn J., Paikoff R.L., Warren M.P. Prediction of eating problems: An 8-year study of adolescent girls // Developmental Psychology. 1994. V. 30. P. 823–834.
6. Graham P., Nunn K. Research in eating disorders: should we focus on the brain? // Advances in Eating Disorders: Theory, Research and Practice. 2013. V.1. N 1, P. 82-97.
7. Grimm E.R., Steinle N.I. Genetics of eating behavior: established and emerging concepts // Nutrition Reviews. 2011. V. 69. N 1. P. 52–60.
8. Horesh N., Apter A., Ishai J., Danziger Y., Miculincer M., Stein D., Lepkifker E., Minouni M. Abnormal psychosocial situations and eating disorders in adolescence // Journal of American Academy of Child and Adolescent Psychiatry. 1996. V. 35. P. 921–927.
9. Hudson J.I., Laird N.M., Betensky R.A., Keck .E., Pope H.G. Multivariate logistic regression for familial aggregation of two disorders. II. Analysis of studies of eating and mood disorders // American Journal of Epidemiology. 2001. V. 153, N 5. P. 506-514.
10. Hudson J.I., Lalonde J.K., Berry J.M., Pindyck L.J.; Bulik C.M., Crow S.J., McElroy S.L., Laird N.M., Tsuang M.T., Walsh B.T., Rosenthal N.R., Pope H.G. Binge-eating disorder as a distinct familial phenotype in obese individuals. // Archives of General Psychiatry. 2006. V. 63. P. 313-319.
11. Jacobi C., Hayward C., de Zwaan M., Kraemer H.C., Agras W.S. Coming to terms with risk factors for eating disorders: application of risk terminology and suggestions for a general taxonomy // Psychological Bulletin. 2004. V. 130. N 1. P. 19–65.
12. Javaras K.N., Laird N.M., Reichborn-Kjennerud T., Bulik C.M., Pope H.G. Jr, Hudson J.I. Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study // International Journal of Eating Disorders. 2008. V. 41. P. 174–179.
13. Kaye W. Neurobiology of anorexia and bulimia nervosa // Physiology and Behavior. 2008. V. 94. N 1. P. 121–135.
14. Klump K.L., Bulik C.M., Kaye W.H., Treasure J., Tyson E. Academy for Eating Disorders position paper: Eating disorders are serious mental illnesses // International Journal of Eating Disorders. 2009. V. 42. P. 97–103.
15. Klump K.L., Suisman J.L., Burt S.A., McGue M., Iacono W.G. Genetic and environmental influences on disordered eating: An adoption study // Journal of Abnormal Psychology. 2009. V. 118. N 4. P. 797–805.
16. Krom de M., Bauer F., Collier D., Adan R.A.H., la Fleur S. E. Genetic variation and effects on human eating behavior // Annual Review of Nutrition. 2009. V. 29. P. 283–304.
17. Le Grange D., Lock J., Loeb K., Nicholls D. Academy for Eating Disorders position paper: the role of the family in eating disorders // International Journal of Eating Disorders. 2010. V. 43. P. 1-5.
18. Lee Y.H., Abbott D.W., Seim H., Crosby R.D., Monson N., Burgard M., Mitchell J.E. Eating disorders and psychiatric disorders in the first-degree relatives of obese probands with binge eating disorder and obese non-binge eating disorder controls // International Journal of Eating Disorders. 1999. V. 26. N 3. P. 322-332.
19. Lilenfeld L.R., Kaye W.H., Greeno C.G., Merikangas K.R., Plotnicov K., Pollice C., Rao R., Strober M., Bulik C.M., Nagy L. A. Controlled family study of anorexia nervosa and bulimia nervosa. Psychiatric disorders in first-degree relatives and effects of proband comorbidity // Archives of General Psychiatry. 1998. V. 55. n 7. P. 603-610.
20. Mangweth B., Hudson J.I., Pope H.G., Hausmann A., De Col C., Laird N.M., Beibl W., Tsuang M.T. Family study of the aggregation of eating disorders and mood disorders // Psychological Medicine. 2003. V. 33. N 7. P. 1319-1323.
21. Mazzeo S.E., Bulik C.M. Environmental and genetic risk factors for eating disorders: What the clinician needs to know // Child and Adolescent Psychiatric Clinics of North America. 2009. V. 18. N 1. P. 67–82.
22. McKnight Investigators. Risk factors for the onset of eating disorders in adolescent girls: Results of the McKnight longitudinal risk factor study. American Journal of Psychiatry. 2003. V. 160. P. 248–254.
23. Miller M., Pumariega A. Culture and eating disorders: A historical and cross-cultural review // Psychiatry. 2001. V. 64. N 2. P. 93-110.
24. Mussell M.P., Binford R.B., Fulkerson J.A. Eating disorders: Summary of risk factors, prevention programming, and prevention research // The Counseling Psychologist. 2000. V. 28. N. 6. P. 764-796.
25. Pjetri E., Schmidt U., Kas M.J., Campbell I.C. Epigenetics and eating disorders // Current Opinion in Clinical Nutrition and Metabolic Care, 2012. V. 15. N 4. P. 330-335.
26. Polivy J. Herman C.P. Causes of eating disorders // Annual Review of Psychology. 2002. V. 53. P. 187-213.
27. Shoebridge P., Gowers S.G. Parental high concern and adolescent-onset anorexia nervosa: A case-control study to investigate direction of causality. British Journal of Psychiatry. 2000. V. 176. P. 132–137.
28. Smink F. R. E., van Hoeken D. Hoek H. W. Epidemiology of eating disorders: incidence, prevalence and mortality rates // Current Psychiatry Reports. 2012. V. 14 P. 406–414.
29. Stein D., Lilenfeld L.R., Plotnicov K., Pollice C., Rao R., Strober M., Kaye W.H. Familial aggregation of eating disorders: Results from a controlled family study of bulimia nervosa // International Journal of Eating Disorders. 1999. V. 26. Is. 2. P. 211–215.
30. Striegel-Moore R.H., Bulik C.M. Risk factors for eating disorders // American Psychologist. 2007. V. 62. N. 3. P. 181–198.
31. Strober M., Freeman R., Lampert C., Diamond J. The association of anxiety disorders and obsessive compulsive personality disorder with anorexia nervosa: evidence from a family study with discussion of nosological and neurodevelopmental implications. International Journal of Eating Disorders. 2007. V. 40. Is. S3. P. S46-S51.
32. Strober M., Freeman R., Lampert C., Diamond J., Kaye W. Controlled family study of anorexia nervosa and bulimia nervosa: Evidence of shared liability and transmission of partial syndromes // American Journal of Psychiatry. 2000. V. 157. P. 393–401.
33. Strober M., Lampert C., Morrell W., Burroughs J., Jacobs C.A. Controlled family study of anorexia nervosa: Evidence of familial aggregation and lack of shared transmission with affective disorders // International Journal of Eating Disorders. 1990. V. 9. Is. 3. P. 239–253.
34. Treasure J., Claudino A.M., Zucker N. Eating disorders // Lancet. 2010. V. 375. P. 583–593.
35. Walters E.E., Neale M.C., Eaves L.J., Heath A.C., Kessler R.C., Kendler K.S. Bulimia nervosa and major depression: a study of common genetic and environmental factors // Psychological Medicine. 1992. V. 22. N 3. P. 617-622.
36. Welch S.L., Doll H.A., Fairburn C.G. Life events and the onset of bulimia nervosa: A controlled study // Psychological Medicine. 1997. V. 27. P. 515–522.