Дополнительные и альтернативные вмешательства при расстройствах аутистического спектра: обзор для родителей и клиницистов ¹⁹³

Методы дополнительных и альтернативных вмешательств (Complementary and Alternative Therapy, CAT), применяемые в работе с детьми с расстройствами аутистического спектра (РАС), распространены в европейских странах и в Российской Федерации, однако их эффективность и безопасность обычно не рассматриваются клиницистами и родителями составлении рекомендаций и использовании. Данный аналитический обзор посвящен наиболее распространенным дополнительным и альтернативным вмешательствам, применяемым в работе с детьми с РАС. На основе анализа информации, представленной в мета-анализах, систематических обзорах и рандомизированных контролируемых исследованиях в базе данных PubMed, рассматриваются безопасность и эффективность каждого вида вмешательств. Обнаружено, что из всех рассмотренных методов только вмешательства с применением мелатонина можно считать безопасными и эффективными для детей с РАС с сопутствующими нарушениями сна. Методы, которые были классифицированы как безопасные, но не доказавшие свою эффективность, рекомендуется применять только в том случае, если они не противоречат терапии РАС «первой линии» – применению прикладного анализа поведения (Applied Behavioral Analysis, ABA). Методы, доказательств эффективности которых обнаружено не было, такие как терапия слуховой интеграции, биоакустическая коррекция, терапия сенсорной интеграции, микрополяризация, пет-терапия и диета, не должны рекомендоваться в качестве альтернативных методов терапии и могут использоваться только в дополнение к методам лечения на основе ABA-вмешательства. Не рекомендуется использовать хелатирование, гипербарическую кислородную терапию и холдинг- терапию по причине их установленного вредоносного психологического и физического воздействия. При выборе методов дополнительных и альтернативных вмешательств при РАС мы рекомендуем родителям и клиницистам использовать критерии, предложенные Н. Лофтхаусом и коллегами (2012): могут быть рекомендованы только безопасные, простые, экономные и разумные методы вмешательств, тогда как методы лечения, которые являются рискованными, трудно реализуемыми или дорогими, использовать не следует.

Ключевые слова: расстройства аутистического спектра, расстройства аутистического спектра (РАС), дополнительные вмешательства, альтернативные вмешательства, CAT, модель безопасность-эффективность

Рубрика: Методы и методики

Тип: научная статья

DOI: https://doi.org/10.17759/cpse.2020090310

Подготовка данной статьи была профинансирована Российским Фондом Фундаментальных Исследований (№17-29-02384, руководитель – Е.Л. Григоренко).

1. Антонова И.Д. Формирование эмоциональной привязанности аутичного ребенка к матери в процессе холдинг-терапии // Дефектология, 2007. Т. 2. С. 3–14.
2. Либлинг М.М. Игровая холдинг терапия при аутизме: методические особенности и этические аспекты применения // Дефектология, 2014. Т. 3. С. 30–44.
3. Мамайчук И.И. Помощь психолога детям с аутизмом. СПб.: Речь, 2007. 288 с.
4. Цыбенко В.Л. Оказание психологической помощи аутичным детям средствами модифицированного варианта холдинг-терапии // Известия Волгоградского государственного педагогического университета, 2008. Т. 1. С. 176–180.
5. Adams J. Vitamin/mineral supplements for children and adults with autism // Vitam Miner 3, 2015. Vol. 4, no. 1, article number 127. DOI: 10.4172/2376-1318.1000127
6. Akins R.S., Angkustsiri K., Hansen R.L. Complementary and alternative medicine in autism: an evidence-based approach to negotiating safe and efficacious interventions with families // Neurotherapeutics, 2010. Vol. 7, no. 3, pp. 307–319. DOI: 10.1016/ j.nurt.2010.05.002
7. American Speech-Language-Hearing Association. Auditory integration training, 2004.URL: https://www.asha.org/policy/PS2004-00218/ (Accessed: 29.09.2020)
8. Asada K., Tojo Y., Hakarino K. et al. Brief Report: Body Image in Autism: Evidence from Body Size Estimation // Journal of Autism and Developmental Disorders, 2018. Vol. 48,
   no. 2, pp. 611–618. DOI: 10.1007/s10803-017-3323-x
9. Barahona-Corrêa J.B., Velosa A., Chainho A. et al. Repetitive transcranial magnetic stimulation for treatment of autism spectrum disorder: A systematic review and meta-analysis // Frontiers in Integrative Neuroscience, 2018. Vol. 12, article number 27. DOI: 10.3389/fnint.2018.00027
10. Barbosa R.S., Vieira-Coelho M.A. Probiotics and prebiotics: Focus on psychiatric disorders–a systematic review // Nutrition Reviews, 2020. Vol. 78, no. 6, pp. 437–450.
11. Barton E.E., Reichow B., Schnitz A. et al. A systematic review of sensory-based treatments for children with disabilities // Research in Developmental Disabilities, 2015. Vol. 37, pp. 64–80. DOI: 10.1016/j.ridd.2014.11.006
12. Bass M.M., Duchowny C.A., Llabre M.M. The effect of therapeutic horseback riding on social functioning in children with autism // Journal of Autism and Developmental Disorders, 2009. Vol. 39, no. 9, pp. 1261–1267. DOI: 10.1007/s10803-009-0734-3
13. Bettison S. The long-term effects of auditory training on children with autism // Journal of Autism and Developmental Disorders, 1996. Vol. 26, no. 3, pp. 361–374.
14. Bogdanov O., Pinchuk D.Y., Pisar'kova E. et al. The use of the method of transcranial micropolarization to decrease the severity of hyperkineses in patients with infantile cerebral palsy // Neuroscience and Behavioral Physiology, 1994. Vol. 24, pp. 442–445.
15. Brondino N., Fusar-Poli L., Rocchetti M. et al. Complementary and alternative therapies for autism spectrum disorder // Evidence-Based Complementary and Alternative Medicine, 2015. Article number 258589. pp. 1–31. DOI: 10.1155/2015/258589
16. Brunoni A.R., Valiengo L., Zanao T. et al. Manic psychosis after sertraline and transcranial direct-current stimulation // The Journal of Neuropsychiatry and Clinical Neurosciences, 2011. Vol. 23, no. 3, E4–E5. DOI: 10.1176/jnp.23.3.jnpe4
17. Buckley A.W., Hirtz D., Oskoui M. et al. Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology // Neurology, 2020. Vol. 94, no. 9, pp. 392–404. DOI: 10.1212/WNL.0000000000009033
18. Carmassi C., Palagini L., Caruso D. et al. Systematic review of sleep disturbances and circadian sleep desynchronization in autism spectrum disorder: Toward an integrative model of a self-reinforcing loop // Frontiers in Psychiatry, 2019. Vol. 10, article number 366, pp. DOI: 10.3389/fpsyt.2019.00366
19. Case-Smith J., Weaver L.L., Fristad M.A. A systematic review of sensory processing interventions for children with autism spectrum disorders // Autism, 2015. Vol. 19, no. 2, pp. 133–148. DOI: 10.1177/1362361313517762
20. Chaffin M., Hanson R., Saunders B.E. et al. Report of the APSAC task force on attachment therapy, reactive attachment disorder, and attachment problems // Child Maltreatment, 2006. Vol. 11, no. 1, pp. 76–89. DOI: 10.1177/1077559505283699
21. Charry-Sánchez J.D., Pradilla I., Talero-Gutiérrez C. Animal-assisted therapy in adults: A systematic review // Complementary Therapies in Clinical Practice, 2018. Vol. 32, no. pp. 169–180. DOI: 10.1016/j.ctcp.2018.06.011
22. Cheng Y.-S., Tseng P.-T., Chen Y.-W. et al. Supplementation of Omega-3 fatty acids may improve hyperactivity, lethargy, and stereotypy in children with autism spectrum disorders: A meta-analysis of randomized controlled trials // Neuropsychiatric Disease and Treatment, 2017. Vol. 13, pp. 2531–2543. DOI: 10.2147/NDT.S147305
23. Crawford C., Boyd C., Paat C.F. et al. The impact of massage therapy on function in pain populations – a systematic review and meta-analysis of randomized controlled trials: Part I, patients experiencing pain in the general population // Pain Medicine, 2016. Vol. 17, no. 7, pp. 1353–1375. DOI: 10.1093/pm/pnw099
24. Cruz R.F., Chodorow J., Berrol C.F. Dance/movement therapists in action: A working guide to research options. Springeld, IL: Charles C. Thomas Publisher. 2018. 233 p.
25. Cuomo B.M., Vaz S., Lee E.A.L. et al. Effectiveness of sleep‐based interventions for children with autism spectrum disorder: A meta‐synthesis // Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2017. Vol. 37, no. 5, pp. 555–578. DOI: 10.1002/phar.1920
26. Edelmuth R.C., Nitsche M.A., Battistella L. et al. Why do some promising brain-stimulation devices fail the next steps of clinical development? // Expert Review of Medical Devices, 2010. Vol. 7, no. 1, pp. 67–97. DOI: 10.1586/erd.09.64
27. Eigsti I.-M. A review of embodiment in autism spectrum disorders // Frontiers in Psychology, 2013. Vol. 4, article number 224. DOI:10.3389/fpsyg.2013.00224
28. Fiene L., Brownlow C. Investigating interoception and body awareness in adults with and without autism spectrum disorder // Autism Research, 2015. Vol. 8, no. 6,
    pp. 709–716. DOI: 10.1002/aur.1486
29. Finisguerra A., Borgatti R., Urgesi C. Non-invasive brain stimulation for the rehabilitation of children and adolescents with neurodevelopmental disorders:
    A systematic review // Frontiers in Psychology, 2019. Vol. 10, article number 135. DOI: 10.3389/fpsyg.2019.00135
30. Gallese V. Intentional attunement: A neurophysiological perspective on social cognition and its disruption in autism // Brain Research, 2006. Vol. 1079, no. 1, pp. 15–24. DOI: 10.1016/j.brainres.2006.01.054
31. Geretsegger M., Elefant C., Mössler K.A. et al. Music therapy for people with autism spectrum disorder // Cochrane Database of Systematic Reviews, 2014. No. 6, Article number CD004381. DOI: 10.1002/14651858.CD004381.pub3
32. Gilmer M.J., Baudino M.N., Tielsch A.G. et al. Animal-assisted therapy in pediatric palliative care // The Nursing Clinics of North America, 2016. Vol. 51, no. 3, pp. 381–395. DOI: 10.1016/j.cnur.2016.05.007
33. Golnik A.E., Ireland M. Complementary alternative medicine for children with autism: A physician survey // Journal of Autism And Developmental Disorders, 2009.
    Vol. 39, no. 7, pp. 996–1005. DOI: 10.1007/s10803-009-0714-7
34. Green V.A., Pituch K.A., Itchon J. et al. Internet survey of treatments used by parents of children with autism // Research in Developmental Disabilities, 2006. Vol. 27, no. 1,
    pp. 70–84. DOI: 10.1016/j.ridd.2004.12.002
35. Grigorenko E., Torres S., Lebedeva E. et al. Evidence-Based Interventions for ASD:
    A focus on Applied Behavior Analysis (ABA) interventions // Psychology. Journal of Higher School of Economics, 2018. Vol. 15, no. 4, pp. 711–727. DOI: 10.17323/1813-8918-2018-4-711-727
36. Guénolé F., Godbout R., Nicolas A. et al. Melatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion // Sleep Medicine Reviews, 2011. Vol. 15, no. 6, pp. 379–387. DOI: 10.1016/j.smrv.2011.02.001.
37. Hall S.E., Riccio C.A. Complementary and alternative treatment use for autism spectrum disorders // Complementary Therapies in Clinical Practice, 2012. Vol. 18, no. 3, pp. 159–163. DOI: 10.1016/j.ctcp.2012.03.004
38. Healy S., Nacario A., Braithwaite R.E. et al. The effect of physical activity interventions on youth with autism spectrum disorder: A meta-analysis: Physical activity interventions // Autism Research, 2018. Vol. 11, no. 6, pp. 818–833. DOI: 10.1002/ aur.1955
39. Hildebrandt M., Koch S., Fuchs T. “We dance and find each other” 1: Effects of dance/movement therapy on negative symptoms in autism spectrum disorder // Behavioral Sciences, 2016. Vol. 6, no. 4, pp. 24. DOI: 10.3390/bs6040024
40. Hirsch L.E., Pringsheim T. Aripiprazole for autism spectrum disorders (ASD) // Cochrane Database of Systematic Reviews, 2016. No. 6, article number CD009043. DOI: 10.1002/14651858.CD009043.pub3.
41. Horvath A., Łukasik J., Szajewska H. Ω-3 fatty acid supplementation does not affect autism spectrum disorder in children: A systematic review and meta-analysis // The Journal of Nutrition, 2017. Vol. 147, no. 3, pp. 367–376. DOI: 10.3945/jn.116.242354
42. Howells K., Sivaratnam C., May T. et al. Efficacy of group-based organised physical activity participation for social outcomes in children with autism spectrum disorder:
    A systematic review and meta-analysis // Journal of Autism And Developmental Disorders, 2019. Vol. 49, no. 8, pp. 3290–3308. DOI: 10.1007/s10803-019-04050-9
43. Iglesias–Vázquez L., Van Ginkel Riba G., Arija V. et al. Composition of gut microbiota in children with autism spectrum disorder: A systematic review and meta-analysis // Nutrients, 2020. Vol. 12, no. 3, article number 792. DOI: 10.3390/nu12030792
44. James S., Montgomery P., Williams K. Omega‐3 fatty acids supplementation for autism spectrum disorders (ASD) // Cochrane Database of Systematic Reviews, 2011, no. 11, article number CD007992. DOI: 10.1002/14651858.CD007992.pub2
45. James S., Stevenson S.W., Silove N. et al. Chelation for autism spectrum disorder (ASD) // Cochrane Database of Systematic Reviews, 2015. No. 5, article number CD010766. DOI: 10.1002/14651858.CD010766
46. Jenabi E., Ataei S., Bashirian S. Evaluation of drug interventions for the treatment of sleep disorders in children with autism spectrum disorders: a systematic review // Korean Journal of Pediatrics, 2019. Vol. 62, no. 11, pp. 405–409.
47. Kamioka H., Okada S., Tsutani K. et al. Effectiveness of animal-assisted therapy:
    A systematic review of randomized controlled trials // Complementary Therapies in Medicine, 2014. Vol. 22, no. 2, pp. 371–390. DOI: 10.1016/j.ctim.2013.12.016
48. Kemper K.J., Cohen M. Ethics meet complementary and alternative medicine: New light on old principles // Contemporary Pediatrics, 2004. Vol. 21, no. 3, pp. 61–69.
49. Kern J.K., Fletcher C.L., Garver C.R. et al. Prospective trial of equine-assisted activities in autism spectrum disorder // Alternative Therapies in Health & Medicine, 2011. Vol. 17, no. 3. pp. 14–20
50. Koch S., Mehl L., Sobanski E., Sieber M. et al. Fixing the mirrors: A feasibility study of the effects of dance movement therapy on young adults with autism spectrum disorder // Autism, 2015. Vol. 19, no. 3, pp. 338–350. DOI: 10.1177/1362361314522353
51. Koch S.C., Riege R.F.F., Tisborn K. et al. Effects of dance movement therapy and dance on health-related psychological outcomes. A meta-analysis update // Frontiers in Psychology, 2019. Vol. 10, article number 1806. pp. DOI: 10.3389/fpsyg.2019.01806
52. Koehne S., Behrends A., Fairhurst M.T. et al. Fostering social cognition through an imitation- and synchronization-based dance/movement intervention in adults with autism spectrum disorder: A controlled proof-of-concept study // Psychotherapy and Psychosomatics, 2016. Vol. 85, no. 1, pp. 27–35. DOI: 10.1159/000441111
53. Kosnett M. Chelation for heavy metals (arsenic, lead, and mercury): Protective or perilous? // Clinical Pharmacology & Therapeutics, 2010. Vol. 88, no. 3, pp. 412–415. DOI: 10.1038/clpt.2010.132
54. Lee M.S., Kim J.-I., Ernst E. Massage therapy for children with autism spectrum disorders: A systematic review // The Journal of Clinical Psychiatry, 2011. Vol. 72, no. 3,
    pp. 406–411. DOI: 10.4088/JCP.09r05848whi
55. Lewis P.M., Thomson R.H., Rosenfeld J.V. et al. Brain neuromodulation techniques:
    A review // The Neuroscientist, 2016. Vol. 22, no. 4, 406–421. DOI: 10.1177/ 1073858416646707
56. Lilienfeld S.O., Fowler K.A., Lohr J.M. et al. Pseudoscience, nonscience, and nonsense in clinicalpsychology: Dangers and remedies. In R.H. Wright, N.A. Cummings (Eds.), Destructive trends in mental health: The well-intentioned path to harm. New York, NY: Routledge. Pp. 187–218.
57. Liu C., Li T., Wang Z. et al. Scalp acupuncture treatment for childrenʼs autism spectrum disorders: A systematic review and meta-analysis // Medicine, 2019. Vol. 98, no. 13, e14880. DOI: 10.1097/MD.0000000000014880
58. Liu J., Wan G.-B., Huang M.-S. et al. Probiotic therapy for treating behavioral and gastrointestinal symptoms in autism spectrum disorder: A systematic review of clinical trials // Current Medical Science, 2019. Vol. 39, no. 2, pp. 173–184. DOI: 10.1007/s11596-019-2016-4
59. Lofthouse N., Hendren R., Hurt E. et al. A review of complementary and alternative treatments for autism spectrum disorders // Autism Research and Treatment, 2012,
    Vol. 2012, article number 870391, pp. 1–21. DOI: 10.1155/2012/870391
60. Ludvigsson J.F., Reichenberg A., Hultman C.M. et al. A nationwide study of the association between celiac disease and the risk of autistic spectrum disorders // JAMA Psychiatry, 2013. Vol. 70, no. 11, pp. 1224–1230. DOI: 10.1001/jamapsychiatry.2013.2048
61. Maber-Aleksandrowicz S., Avent C., Hassiotis A. A systematic review of animal-assisted therapy on psychosocial outcomes in people with intellectual disability // Research in Developmental Disabilities, 2016. Vol. 49-50, pp. 322–338. DOI: 10.1016/j.ridd.2015.12.005
62. MacDonald M., Lord C., Ulrich D.A. The relationship of motor skills and social communicative skills in school-aged children with autism spectrum disorder // Adapted Physical Activity Quarterly, 2013. Vol. 30, no. 3, pp. 271–282. DOI: 10.1123/apaq.30.3.271
63. MacPherson H., Richmond S., Bland M. et al. Acupuncture and counselling for depression in primary care: A randomised controlled trial // PLoS Medicine, 2013. Vol. 10, no. 9, e1001518. DOI: 10.1371/journal.pmed.1001518
64. Mari-Bauset S., Zazpe I., Mari-Sanchis A. et al. Evidence of the gluten-free and casein-free diet in autism spectrum disorders: A systematic review // Journal of Child Neurology, 2014. Vol. 29, no. 12, pp. 1718–1727. DOI: 10.1177/0883073814531330
65. Martin F., Farnum J. Animal-assisted therapy for children with pervasive developmental disorders // Western Journal of Nursing Research, 2002. Vol. 24, no. 6,
    pp. 657–670. DOI: 10.1177/019394502320555403
66. Mastrominico A., Fuchs T., Manders E. et al. Effects of dance movement therapy on adult patients with autism spectrum disorder: A randomized controlled trial // Behavioral Sciences, 2018. Vol. 8, no. 7, article number 61. DOI: 10.3390/bs8070061
67. Mazahery H., Stonehouse W., Delshad M. et al. Relationship between long chain n-3 polyunsaturated fatty acids and autism spectrum disorder: Systematic review and meta-analysis of case-control and randomised controlled trials // Nutrients, 2017. Vol. 9, no. 2, article number 155. DOI: 10.3390/nu9020155
68. McDonagh M.S., Holmes R., Hsu F. Pharmacologic treatments for sleep disorders in children: A systematic review // Journal of Child Neurology, 2019. Vol. 34, no. 5,
    pp. 237–247. DOI: 10.1177/0883073818821030
69. McLay L.-L.K., France K. Empirical research evaluating non-traditional approaches to managing sleep problems in children with autism // Developmental Neurorehabilitation, 2016. Vol. 19, no. 2, pp. 123–134. DOI: 10.3109/17518423. 2014. 904452
70. Mehl-Madrona L., Leung B., Kennedy C. et al. Micronutrients versus standard medication management in autism: A naturalistic case-control study // Journal of Child and Adolescent Psychopharmacology, 2010. Vol. 20, no. 2, pp. 95–103. DOI: 10.1089/cap. 2009.0011
71. Mercer J. Holding therapy: A harmful mental health intervention // Focus on Alternative and Complementary Therapies an Evidence-based Approach, 2013. Vol. 18,
    no. 2, pp. 70–76.
72. National Center for Complementary and Integrative Health. Acupuncture: In depth. National Institutes of Health. 2016. URL: https://www.nccih.nih.gov/health/acupuncture-in-depth (Accessed: 17.07.2020)
73. National Center for Complementary and Integrative Health. Complementary, alternative, or integrative health: what’s in a name? 2015. URL: https://www.nccih.nih. gov/health/complementary-alternative-or-integrative-health-whats-in-a-name (Accessed: 17.07.2020)
74. Ng Q.X., Loke W., Venkatanarayanan N. et al. A systematic review of the role of prebiotics and probiotics in autism spectrum disorders // Medicina, 2019. Vol. 55, no. 5, article number 129. DOI: 10.3390/medicina55050129
75. Nimer J., Lundahl B. Animal-assisted therapy: A meta-analysis // Anthrozoös, 2007. Vol. 20, no. 3, pp. 225–238. DOI: 10.2752/089279307X224773
76. O’Haire M.E. Animal-assisted intervention for autism spectrum disorder: A systematic literature review // Journal of Autism and Developmental Disorders, 2013.
    Vol. 43, no. 7, pp. 1606–1622. DOI: 10.1007/s10803-012-1707-5
77. Parker A., Beresford B., Dawson V. et al. Oral melatonin for non‐respiratory sleep disturbance in children with neurodisabilities: Systematic review and meta‐analyses // Developmental Medicine & Child Neurology, 2019. Vol. 61, no. 8, pp. 880–890. DOI: 10.1111/dmcn.14157
78. Peper C.L.E., van der Wal S.J., Begeer S. Autism in action: Reduced bodily connectedness during social interactions? // Frontiers in Psychology, 2016. Vol. 7, article number 1862. DOI: 10.3389/fpsyg.2016.01862
79. Piwowarczyk A., Horvath A., Łukasik J. et al. Gluten-and casein-free diet and autism spectrum disorders in children: A systematic review // European Journal of Nutrition, 2018. Vol. 57, no. 2, pp. 433–440. DOI: 10.1007/s00394-017-1483-2
80. Ranjan S., Nasser J.A. Nutritional status of individuals with autism spectrum disorders: Do we know enough? // Advances in Nutrition, 2015. Vol. 6, no. 4, pp. 397–407. DOI: 10.3945/an.114.007914
81. Reissmann A., Hauser J., Makulska-Gertruda E. et al. Gluten-free and casein-free diets in the treatment of autism // Functional Foods in Health and Disease, 2014. Vol. 4,
    no. 8, pp. 349–361.
82. Rianda D., Agustina R., Setiawan E. et al. Effect of probiotic supplementation on cognitive function in children and adolescents: A systematic review of randomised trials // Beneficial Microbes, 2019. Vol. 10, no. 8, pp. 873–882. DOI: 10.3920/BM2019.0068
83. Rossignol D.A., Frye R.E. Melatonin in autism spectrum disorders: A systematic review and meta‐analysis // Developmental Medicine & Child Neurology, 2011. Vol. 53,
    no. 9, pp. 783–792. DOI: 10.1111/j.1469-8749.2011.03980.x
84. Rossignol D.A., Rossignol L.W., Smith S. et al. Hyperbaric treatment for children with autism: A multicenter, randomized, double-blind, controlled trial // BMC Pediatrics, 2009. Vol. 9, no. 1, article numner 21. DOI: 10.1186/1471-2431-9-21
85. Salomone E., Charman T., McConachie H. et al. Prevalence and correlates of use of complementary and alternative medicine in children with autism spectrum disorder in Europe // European Journal of Pediatrics, 2015. Vol. 174, no. 10, pp. 1277–1285. DOI: 10.1007/s00431-015-2531-7
86. Sandbank M., Bottema-Beutel K., Crowley S. et al. Project AIM: Autism intervention meta-analysis for studies of young children // Psychological Bulletin, 2020. Vol. 146, no. 1. DOI: 10.1037/bul0000215
87. Sathe N., Andrews J.C., McPheeters M.L. et al. Nutritional and dietary interventions for autism spectrum disorder: A systematic review // Pediatrics, 2017. Vol. 139, no. 6, e20170346. DOI: 10.1542/peds.2017-0346
88. Schoen S.A., Lane S.J., Mailloux Z. et al. A systematic review of Ayres Sensory Integration intervention for children with autism // Autism Research, 2019. Vol. 12, no. 1, pp. 6–19. DOI: 10.1002/aur.2046
89. Sharma A., Shaw S.R. Efficacy of risperidone in managing maladaptive behaviors for children with autistic spectrum disorder: A meta-analysis // Journal of Pediatric Health Care, 2012. Vol. 26, no. 4, pp. 291–299. DOI: 10.1016/j.pedhc.2011.02.008
90. Shelyakin A., Preobrazhenskaya I., Pisar’kova E. et al. Effects of transcranial micropolarization of the frontal cortex on the state of motor and cognitive functions in extrapyramidal pathology // Neuroscience and Behavioral Physiology, 1998. Vol. 28, no. 4, pp. 468–471.
91. Sinha Y., Silove N., Wheeler D. et al. Auditory integration training and other sound therapies for autism spectrum disorders: A systematic review // Archives of Disease in Childhood, 2006. Vol. 91, no. 12, pp. 1018–1022. DOI: 10.1136/adc.2006.094649
92. Sliwinski S., Croonenberghs J., Christophe A. et al. Polyunsaturated fatty acids:
    Do they have a role in the pathophysiology of autism? // Neuroendocrinology Letters,
    2006. Vol. 27, no. 4, pp. 465–472. URL: http://www.nel.edu/userfiles/articlesnew/ NEL270406A09.pdf (Accessed: 17.07.2020).
93. Sowa M., Meulenbroek R. Effects of physical exercise on autism spectrum disorders: A meta-analysis // Research in Autism Spectrum Disorders, 2012. Vol. 6, no. 1, pp. 46–57. DOI: 10.1016/j.rasd.2011.09.001
94. Sumner E., Leonard H.C., Hill E.L. Overlapping phenotypes in autism spectrum disorder and developmental coordination disorder: A cross-syndrome comparison of motor and social skills // Journal of Autism and Developmental Disorders, 2016. Vol. 46, no. 8, pp. 2609–2620. DOI: 10.1007/s10803-016-2794-5
95. Tortella G., Casati R., Aparicio L.V. et al. Transcranial direct current stimulation in psychiatric disorders // World Journal of Psychiatry, 2015. Vol. 5, no. 1, pp. 88–102. DOI: 10.5498/wjp.v5.i1.88
96. Walaszek R., Maśnik N., Marszałek A. et al. Massage efficacy in the treatment of autistic children – a literature review // International Journal of Developmental Disabilities, 2018. Vol. 64, no. 4-5, pp. 225–229. DOI: 10.1080/20473869.2017.1305139
97. Watling R., Hauer S. Effectiveness of Ayres Sensory Integration® and sensory-based interventions for people with autism spectrum disorder: A systematic review // American Journal of Occupational Therapy, 2015. Vol. 69, no. 5, 6905180030p1-12. DOI 10.5014/ajot.2015.018051
98. Weitlauf A.S., Sathe N., McPheeters M.L. et al. Interventions targeting sensory challenges in autism spectrum disorder: A systematic review // Pediatrics, 2017. Vol. 139, no. 6, e20170347. DOI: 10.1542/peds.2017-0347
99. Whipple J. Music in intervention for children and adolescents with autism: A meta-analysis // Journal of Music Therapy, 2004. Vol. 41, no. 2, pp. 90–106. DOI: 10.1093/ jmt/41.2.90
100. Whiteley P., Shattock P. Biochemical aspects in autism spectrum disorders: Updating the opioid-excess theory and presenting new opportunities for biomedical intervention // Expert Opinion on Therapeutic Targets, 2002. Vol. 6, no. 2, pp. 175–183. DOI: 10.1517/14728222.6.2.175
101. Xiong T., Chen H., Luo R., Mu D. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD) // Cochrane Database of Systematic Reviews, 2016. No. 10, article number CD010922. DOI: 10.1002/14651858.CD010922.pub2
102. Yakovlev N., Kositskaya Z., Klimenko V. et al. Decreases in the severity of affective disorders in patients with onset of schizophrenia using bioacoustic correction // Neuroscience and Behavioral Physiology, 2013. Vol. 43, no. 3, pp. 363–366.
103. Yang Y.-J., Siao M.-R., Tsai F.-T. et al. Effect of physical activity interventions on children and adolescents with autism spectrum disorder: A systematic review and meta-analysis // Physiotherapy, 2015. Vol. 101, no. e1685–e1686.