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Consortium Psychiatricum
2024. Том 5. № 3. С. 31–41
doi:10.17816/CP15525
ISSN: 2712-7672 / 2713-2919 (online)

Биологические методы диагностики депрессивных симптомов при шизофрении: нарративный обзор литературы

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Султанова Р.И., Гашкаримов В.Р., Ефремов И.С., Асадуллин А.Р.

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Аннотация

ВВЕДЕНИЕ: Депрессивная симптоматика при шизофрении приводит к более частым обострениям основного заболевания, ухудшению прогноза и повышению риска суицида. Перед клиницистами до сих пор стоит вопрос, связанный с трудностями диагностики этого расстройства.

ЦЕЛЬ: Произвести обзор литературы, направленный на поиск информации о биомаркерах депрессивных проявлений при шизофрении.

МЕТОДЫ: Поиск данных литературы осуществляли с применением следующих электронных сервисов для поиска публикаций (также указано общее число источников, обнаруженных по искомой теме): ACCESSSS (n=150), Cochrane Library (n=48), PubMed (n=623), eLIBRARY (n=216), Google Scholar (n=367). В итоговое обсуждение было включено 67 публикаций, соответствующих цели работы и опубликованных не ранее 01.01.2018 и не позднее 31.12.2023.

РЕЗУЛЬТАТЫ: При суммировании разрозненных данных предположено, что плазменные показатели (концентрация С-реактивного белка, метаболические, гормональные, ферментативные показатели, значения нейротрофических факторов) слабоспецифичны для диагностики депрессивных симптомов при шизофрении. С помощью методов нейровизуализации установлено, что уменьшение объема серого вещества в теменной, лобной и височной доле (особенно в зонах Брока и Вернике), а также в префронтальной коре — в медиальной части правой верхней лобной, медиальной орбитофронтальной, верхней и средней фронтальных извилины — связано с депрессивными проявлениями. Предполагается связь между генами SIRT1, OXT, CDKAL1 и APOE в возникновении депрессивных симптомов у пациентов с шизофренией.

ЗАКЛЮЧЕНИЕ: Понимание и выявление депрессивных симптомов при шизофрении позволит улучшить качество помощи, получаемой пациентами с этим расстройством.

Общая информация

Ключевые слова: симптомы депрессии, шизофрения, нейробиология

Рубрика издания: Обзоры

Тип материала: научная статья

DOI: https://doi.org/10.17816/CP15525

Получена: 26.03.2024

Принята в печать:

Для цитаты: Султанова Р.И., Гашкаримов В.Р., Ефремов И.С., Асадуллин А.Р. Биологические методы диагностики депрессивных симптомов при шизофрении: нарративный обзор литературы // Consortium Psychiatricum. 2024. Том 5. № 3. С. 31–41. DOI: 10.17816/CP15525

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Информация об авторах

Султанова Рената Ильдаровна, Врач-психиатр, ГБУЗ «Научно-практический психоневрологический центр имени З.П. Соловьева» Департамента здравоохранения города Москвы , Москва, Россия, ORCID: https://orcid.org/0000-0001-6679-4454, e-mail: renatasu@mail.ru

Гашкаримов Вадим Римович, Врач-психиатр, ГБУЗ «Республиканская клиническая психиатрическая больница» Минздрава Республики Башкортостан, Уфа, Россия, ORCID: https://orcid.org/0000-0001-9944-141X, e-mail: gashkarimov@yandex.ru

Ефремов Илья Сергеевич, кандидат медицинских наук, Ассистент кафедры психиатрии, наркологии и психотерапии с курсами ИДПО, ФГБОУ ВО «Башкирский Государственный Медицинский Университет» Минздрава России, Младший научный сотрудник, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Уфа, Россия, ORCID: https://orcid.org/0000-0002-9994-8656, e-mail: efremovilya102@gmail.com

Асадуллин Азат Раилевич, доктор медицинских наук, Профессор кафедры психиатрии, наркологии и психотерапии с курсами ИДПО, ФГБОУ ВО «Башкирский Государственный Медицинский Университет» Минздрава России, Ведущий научный сотрудник ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России; Заместитель главного врача по медицинской части, ГБУЗ «Республиканский клинический психотерапевтический центр» Минздрава Республики Башкортостан, Уфа, Россия, ORCID: https://orcid.org/0000-0001-7148-4485, e-mail: droar@yandex.ru

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