Consortium Psychiatricum
2024. Том 5. № 2. С. 5–15
doi:10.17816/CP15494
ISSN: 2712-7672 / 2713-2919 (online)
Генетические ассоциации ангедонии: новые аспекты взаимосвязи психических и соматических расстройств
Аннотация
ВВЕДЕНИЕ: Ангедония характеризуется снижением способности предвосхищать, испытывать и/или усваивать удовольствие. Этот феномен имеет трансдиагностическую природу и является одним из ключевых симптомов расстройств настроения, шизофрении, аддикций и соматических состояний.
ЦЕЛЬ: Оценить генетическую архитектуру ангедонии и её перекрытие с другими психическими расстройствами и соматическими состояниями.
МЕТОДЫ: Проведено исследование полногеномного поиска ассоциаций ангедонии на выборке из 4 520 человек из российской неклинической популяции. Используя доступную сводную статистику, мы рассчитали шкалы полигенного риска (polygenic risk scores, PRS), чтобы исследовать генетическую связь между ангедонией и другими психиатрическими или соматическими фенотипами.
РЕЗУЛЬТАТЫ: Не было идентифицировано ни одного варианта, достигшего полногеномного уровня значимости. PRS для депрессии, биполярного расстройства и шизофрении были значимо ассоциированы с ангедонией. И наоборот, не обнаружено значимых ассоциаций между PRS для тревожных расстройств и ангедонии, что хорошо согласуется с существующими клиническими данными. Ни один из PRS для соматических фенотипов не достиг уровня значимости после коррекции на множественные сравнения. При номинальном уровне значимости ассоциация с ангедонией выявлена для PRS ω-3 жирных кислот, сахарного диабета 2-го типа и болезни Крона.
ЗАКЛЮЧЕНИЕ: Ангедония имеет сложную полигенную архитектуру, в связи с чем её присутствие при соматических заболеваниях или нормальных состояниях может быть обусловлено генетической предрасположенностью к расстройствам настроения или шизофрении.
Общая информация
Ключевые слова: ангедония, депрессия, биполярное расстройство, шизофрения, риски
Рубрика издания: Исследования
Тип материала: научная статья
DOI: https://doi.org/10.17816/CP15494
Получена: 10.01.2024
Принята в печать:
Для цитаты: Касьянов Е.Д., Пинахина Д.В., Ракитько А.С., Вергасова Е., Ермакович Д.П., Рукавишников Г.В., Малышко Л.В., Попов Я.В., Коваленко Е.В., Ильинская А.Ю., Ким А.А., Плотников Н.А., Незнанов Н.Г., Ильинский В.В., Кибитов А.О., Мазо Г.Э. Генетические ассоциации ангедонии: новые аспекты взаимосвязи психических и соматических расстройств // Consortium Psychiatricum. 2024. Том 5. № 2. С. 5–15. DOI: 10.17816/CP15494
Дополнительные материалы
С приложениями к статье можно ознакомиться на сайте Журнала https://doi.org/10.17816/CP15494
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