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Consortium Psychiatricum
2024. Том 5. № 2. С. 45–61
doi:10.17816/CP15514
ISSN: 2712-7672 / 2713-2919 (online)

Гематологические коэффициенты воспаления при психических расстройствах в подростковом возрасте: обзор предметного поля Обложка

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Попов М.Ю., Попов Ю.В., Костерин Д.Н., Лепик О.В.

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Аннотация

ВВЕДЕНИЕ: Гематологические коэффициенты воспаления (ГКВ), такие как нейтрофильно-лимфоцитарное, моноцитарно-лимфоцитарное, тромбоцитарно-лимфоцитарное отношение, ассоциированы с психическими расстройствами, их тяжестью, фазой заболевания. Данные, полученные у взрослых пациентов, обобщены в систематических обзорах и метаанализах. Результаты подобных исследований у подростков не систематизированы.

ЦЕЛЬ: Обобщить результаты исследований, в которых изучали связь ГКВ с психическими расстройствами у пациентов подросткового возраста.

МЕТОДЫ: В обзор предметного поля включали исследования ГКВ у пациентов в возрасте 10–19 лет с психическими расстройствами (кроме нервной анорексии), результаты которых опубликованы на английском языке до 31 декабря 2023 года. Поиск потенциально релевантных работ проводили в базе данных MEDLINE. Отобранные работы анализировали, разделив их на 2 группы: исследования с внешним контролем (здоровые подростки) и исследования с внутренним контролем (пациенты с разной фазой психического расстройства, наличием/отсутствием аутоагрессивного поведения).

РЕЗУЛЬТАТЫ: В обзор включены результаты 11 кросс-секционных исследований. Анализ их результатов показал: 1) у подростков с психическими расстройствами (депрессия, психотические расстройства, обсессивно-компульсивное расстройство, синдром дефицита внимания и гиперактивности, расстройства, связанные с употреблением психоактивных веществ) значения ГКВ выше, чем у их сверстников без соответствующих расстройств (5 исследований); 2) значения ГКВ положительно коррелируют с выраженностью психопатологических симптомов (1 исследование); 3) высокие значения ГКВ связаны с фазой психического расстройства — манией при биполярном аффективном расстройстве (1 исследование) и обострением психоза при психотических расстройствах (1 исследование); 4) высокие значения ГКВ связаны с аутоагрессивным поведением — суицидными попытками (1 исследование) и несуицидальными самоповреждениями (1 исследование).

ЗАКЛЮЧЕНИЕ: ГКВ связаны с психическими расстройствами у подростков, их тяжестью/остротой (выраженностью симптомов, фазой заболевания, наличием аутоагрессии). Для оценки диагностической и прогностической ценности ГКВ в качестве биомаркеров психических расстройств в подростковом возрасте необходимы дальнейшие исследования более высокого методологического качества.

Общая информация

Ключевые слова: системное воспаление, психические расстройства, подростки, биомаркеры

Рубрика издания: Обзоры

Тип материала: научная статья

DOI: https://doi.org/10.17816/CP15514

Получена: 12.02.0204

Принята в печать:

Для цитаты: Попов М.Ю., Попов Ю.В., Костерин Д.Н., Лепик О.В. Гематологические коэффициенты воспаления при психических расстройствах в подростковом возрасте: обзор предметного поля Обложка // Consortium Psychiatricum. 2024. Том 5. № 2. С. 45–61. DOI: 10.17816/CP15514

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Информация об авторах

Попов Михаил Юрьевич, доктор медицинских наук, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Санкт-Петербург, Россия, ORCID: https://orcid.org/0000-0002-7905-4583, e-mail: popovmikhail@mail.ru

Попов Юрий Васильевич, доктор медицинских наук, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Профессор, главный научный сотрудник отделения лечения психических расстройств у подростков и молодых взрослых, Санкт-Петербург, Россия, ORCID: https://orcid.org/0000-0003-1644-8080, e-mail: popov62@yandex.ru

Костерин Дмитрий Николаевич, Научный сотрудник Врач психиатр, Отделение лечения психических расстройств у лиц молодого возраста, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Санкт-Петербург, Россия, ORCID: https://orcid.org/0000-0003-3677-2144

Лепик Ольга Витальевна, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Санкт-Петербург, Россия, ORCID: https://orcid.org/0000-0001-9516-4427, e-mail: ovlepik@gmail.com

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